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Glucagon, GLP-1 and thermogenesis.
Int. J. Mol. Sci. 20:3445 (2019)
Brown adipose tissue (BAT) thermogenesis is a conserved mechanism to maintain body temperature in mammals. However, since BAT contribution to energy expenditure can represent a relevant modulator of metabolic homeostasis, many studies have focused on the nervous system and endocrine factors that control the activity of this tissue. There is long-established evidence that the counter-regulatory hormone glucagon negatively influences energy balance, enhances satiety, and increases energy expenditure. Despite compelling evidence showing that glucagon has direct action on BAT thermogenesis, recent findings are questioning this conventional attribute of glucagon action. Glucagon like peptide-1 (GLP-1) is an incretin secreted by the intestinal tract which strongly decreases feeding, and, furthermore, improves metabolic parameters associated with obesity and diabetes. Therefore, GLP-1 receptors (GLP-1-R) have emerged as a promising target in the treatment of metabolic disorders. In this short review, we will summarize the latest evidence in this regard, as well as the current therapeutic glucagon- and GLP-1-based approaches to treating obesity.
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Publication type
Article: Journal article
Document type
Review
Keywords
Glucagon ; Glp1 ; Thermogenesis ; Brown Adipose Tissue ; Browning ; Hypothalamic Control Of Energy Balance; Brown Adipose-tissue; Dependent Insulinotropic Polypeptide; Spontaneous Meal Size; Invariant Nkt Cells; Killer T-cells; Food-intake; Peptide-1 Receptor; Hypothalamic Ampk; Thyroid-hormones; Gene-expression
ISSN (print) / ISBN
1422-0067
e-ISSN
1661-6596
Quellenangaben
Volume: 20,
Issue: 14,
Article Number: 3445
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)