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Doryab, A. ; Tas, S.* ; Taskin, M.B.* ; Yang, L.* ; Hilgendorff, A. ; Groll, J.* ; Wagner, D.E.* ; Schmid, O.

Evolution of bioengineered lung models: Recent advances and challenges in tissue mimicry for studying the role of mechanical forces in cell biology.

Adv. Func. Mat. 29:1903114 (2019)

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DOI

	Open Access Green

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Mechanical stretch under both physiological (breathing) and pathophysiological (ventilator-induced) conditions is known to significantly impact all cellular compartments in the lung, thereby playing a pivotal role in lung growth, regeneration and disease development. In order to evaluate the impact of mechanical forces on the cellular level, in vitro models using lung cells on stretchable membranes have been developed. Only recently have some of these cell-stretching devices become suitable for air-liquid interface cell cultures, which is required to adequately model physiological conditions for the alveolar epithelium. To reach this goal, a multi-functional membrane for cell growth balancing biophysical and mechanical properties is critical to mimic (patho)physiological conditions. In this review, i) the relevance of cyclic mechanical forces in lung biology is elucidated, ii) the physiological range for the key parameters of tissue stretch in the lung is described, and iii) the currently available in vitro cell-stretching devices are discussed. After assessing various polymers, it is concluded that natural-synthetic copolymers are promising candidates for suitable stretchable membranes used in cell-stretching models. This work provides guidance on future developments in biomimetic in vitro models of the lung with the potential to function as a template for other organ models (e.g., skin, vessels).

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Air-liquid Interface Cell Culture ; Alveolar-capillary Barrier ; In Vitro Cell-stretching Model ; Porous Ultra-thin Scaffolds ; Tunable Polymeric Membranes; Alveolar Epithelial-cells; Strain-induced Differentiation; Obstructive Pulmonary-disease; Deformation-induced Injury; In-vitro; Extracellular-matrix; Nanofibrous Structures; Induced Proliferation; Surfactant Secretion; Protein Adsorption

ISSN (print) / ISBN 1616-301X

e-ISSN 1616-3028

Journal Advanced functional materials

Quellenangaben Volume: 29, Issue: 39, Article Number: 1903114

Publisher Wiley

Publishing Place Weinheim

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Lung Health and Immunity (LHI)