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Stemmer, K. ; Müller, T.D. ; DiMarchi, R.D.* ; Pfluger, P.T. ; Tschöp, M.H.

CNS-targeting pharmacological interventions for the metabolic syndrome.

J. Clin. Invest. 130, 4058-4071 (2019)
Publ. Version/Full Text Preprint Research data DOI PMC
Open Access Gold
The metabolic syndrome (MetS) encompasses medical conditions such as obesity, hyperglycemia, high blood pressure, and dyslipidemia that are major drivers for the ever-increasing prevalence of type 2 diabetes, cardiovascular diseases, and certain types of cancer. At the core of clinical strategies against the MetS is weight loss, induced by bariatric surgery, lifestyle changes based on calorie reduction and exercise, or pharmacology. This Review summarizes the past, current, and future efforts of targeting the MetS by pharmacological agents. Major emphasis is given to drugs that target the CNS as a key denominator for obesity and its comorbid sequelae.
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Publication type Article: Journal article
Document type Review
Keywords Glucagon-like Peptide-1; Controlled-release Phentermine/topiramate; Dependent Insulinotropic Peptide; Cannabinoid-1 Receptor Blocker; Melanin-concentrating Hormone; Neurons Regulate Energy; Once-daily Liraglutide; Diet-induced Obesity; Food-intake; Weight-loss
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 0021-9738
e-ISSN 1558-8238
Journal Journal of Clinical Investigation
Quellenangaben Volume: 130, Issue: 10, Pages: 4058-4071 Article Number: , Supplement: ,
Publisher American Society of Clinical Investigation
Publishing Place 2015 Manchester Rd, Ann Arbor, Mi 48104 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 90000 - German Center for Diabetes Research
30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-221
G-502294-001
DOI 10.1172/JCI129195
WOS ID WOS:000488537800014
Scopus ID 85071171615
PubMed ID 31380808
Erfassungsdatum 2019-08-14
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