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Osteopontin as a link between inflammation and cancer: The thorax in the spotlight.
Cells 8:815 (2019)
The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and extracellular matrix (ECM) function. On the contrary, osteopontin can be deleterious for the human body during disease. Indeed, osteopontin is a cardinal mediator of tumor-associated inflammation and facilitates metastasis. The purpose of this review is to highlight the importance of osteopontin in malignant processes, focusing on lung and pleural tumors as examples.
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Publication type
Article: Journal article
Document type
Review
Keywords
Opn ; Spp1 ; Inflammation ; Lung Cancer ; Secreted Phosphoprotein 1
Language
english
Publication Year
2019
HGF-reported in Year
2019
ISSN (print) / ISBN
2073-4409
e-ISSN
2073-4409
Journal
Cells
Quellenangaben
Volume: 8,
Issue: 8,
Article Number: 815
Publisher
MDPI
Publishing Place
Basel
Institute(s)
Institute of Lung Health and Immunity (LHI)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Lung Research
PSP Element(s)
G-501600-003
PubMed ID
31382483
Erfassungsdatum
2019-08-13