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Jones, L.* ; Holmans, P.A.* ; Hamshere, M.L.* ; Harold, D.* ; Moskvina, V.* ; Ivanov, D.* ; Pocklington, A.* ; Abraham, R.* ; Hollingworth, P.* ; Sims, R.* ; Gerrish, A.* ; Pahwa, J.S.* ; Jones, N.* ; Stretton, A.* ; Morgan, A.R.* ; Lovestone, S.* ; Powell, J.* ; Proitsi, P.* ; Lupton, M.K.* ; Brayne, C.* ; Rubinsztein, D.C.* ; Gill, M.* ; Lawlor, B.* ; Lynch, A.* ; Morgan, K.* ; Brown, KS.* ; Passmore, P.A.* ; Craig, D.* ; McGuinness, B.* ; Todd, S.* ; Holmes, C.* ; Mann, D.* ; Smith, A.D.* ; Love, S.* ; Kehoe, P.G.* ; Mead, S.* ; Fox, N.* ; Rossor, M.* ; Collinge, J.* ; Maier, W.* ; Jessen, F.* ; Schürmann, B.* ; van den Bussche, H.* ; Heuser, I.* ; Peters, O.* ; Kornhuber, J.* ; Wiltfang, J.* ; Dichgans, M.* ; Frölich, L.* ; Hampel, H.* ; Hüll, M.* ; Rujescu, D.* ; Goate, A.M.* ; Kauwe, J.S.* ; Cruchaga, C.* ; Nowotny, P.* ; Morris, J.C.* ; Mayo, K.* ; Livingston, G.* ; Bass, N.J.* ; Gurling, H.* ; McQuillin, A.* ; Gwilliam, R.* ; Deloukas, P.* ; Al-Chalabi, A.* ; Shaw, C.E.* ; Singleton, A.B.* ; Guerreiro, R.* ; Mühleisen, T.W.* ; Nöthen, M.M.* ; Moebus, S.* ; Jöckel, K.-H.* ; Klopp, N. ; Wichmann, H.-E. ; Rüther, E.* ; Carrasquillo, M.M.* ; Pankratz, V.S.* ; Younkin, S.G.* ; Hardy, J.* ; O'Donovan, M.C.* ; Owen, M.J.* ; Williams, J.*

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

PLoS ONE 5:e13950 (2010)
Publ. Version/Full Text Volltext DOI PMC
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Background: Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in the early 1990s. We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes. Methodology: We applied a recently developed tool for mining GWAS data for biologically meaningful information to a LOAD GWAS dataset. The principal findings were then tested in an independent GWAS dataset. Principal Findings: We found a significant overrepresentation of association signals in pathways related to cholesterol metabolism and the immune response in both of the two largest genome-wide association studies for LOAD. Significance: Processes related to cholesterol metabolism and the innate immune response have previously been implicated by pathological and epidemiological studies of Alzheimer's disease, but it has been unclear whether those findings reflected primary aetiological events or consequences of the disease process. Our independent evidence from two large studies now demonstrates that these processes are aetiologically relevant, and suggests that they may be suitable targets for novel and existing therapeutic approaches.
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Publication type Article: Journal article
Document type Scientific Article
Editors Joseph El, K.h.o.u.r.y.* ; Massachusetts General Hospital and Harvard Medical, S.c.h.o.o.l.* ; United States of, A.m.e.r.i.c.a.*
Keywords GENOME-WIDE ASSOCIATION; IDENTIFIES VARIANTS; APOLIPOPROTEIN-E; DEMENTIA; RISK; BETA; INFLAMMATION; POPULATION; MICROGLIA; PATHWAYS
Language english
Publication Year 2010
HGF-reported in Year 2010
ISSN (print) / ISBN 1932-6203
Journal PLoS ONE
Quellenangaben Volume: 5, Issue: 11, Pages: , Article Number: e13950 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place Lawrence, Kan.
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503900-003
G-504090-001
PubMed ID 21085570
DOI 10.1371/journal.pone.0013950
WOS ID 000284231800004
Scopus ID 78649573450
Erfassungsdatum 2010-12-03
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