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Open Access Green as soon as Postprint is submitted to ZB.
Signal transduction by the Epstein-Barr virus oncogene latent membrane protein 1 (LMP1).
Signal Transduct. 7, 20-33 (2007)
The latent membrane protein 1 (LMP1) of Epstein-Barr virus is a viral oncogene with the potential to antagonize apoptosis and senescence as well as to promote cellular survival and proliferation. LMP1 acts like a constitutively active receptor recruiting signalling molecules typically employed by the cellular tumour necrosis factor-receptor (TNF-R) and Toll-like/interleukin-1-receptor (TIR) families. LMP1 activates the classical and alternative NF-jB pathways, c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), the JAK/STAT and phosphatidylinositol 3-kinase (PI3K) pathways. In this article, interactions of LMP1 with host cell signal transduction pathways and their role in LMP1-induced cell transformation are reviewed.
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Publication type
Article: Journal article
Document type
Review
Keywords
LMP1; viral oncogene; transformation; NF-jB; JNK; viral signalling
ISSN (print) / ISBN
1615-4053
e-ISSN
1615-4061
Quellenangaben
Volume: 7,
Issue: 1,
Pages: 20-33
Publisher
Wiley
Publishing Place
Weinheim
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Gene Vector (AGV)