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Are lifestyle therapies effective for NAFLD treatment?
Trends Endocrinol. Metab. 30, 701-709 (2019)
Nonalcoholic fatty liver disease (NAFLD) is becoming the most common liver disorder worldwide. Specifically, nonalcoholic steatohepatitis (NASH) and fibrosis pose an enormous burden for patients and health-care systems. In the absence of approved pharmacological therapies effective lifestyle interventions for NAFLD, such as dietary strategies and exercise training are currently the therapeutic strategies of choice. This review covers the influence of macro-nutrient quality and quantity (i.e., low-carbohydrate and high-protein diets), for successful reduction of intrahepatocellular lipids (IHL). Moreover, we discuss the effectiveness of different modalities of physical exercising with and without weight loss. These lifestyle modifications not only provide strategies to reduce IHL but may also hold a still underestimatec potential to induce improvement and/or even remission of NAFLD.
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Publication type
Article: Journal article
Document type
Review
Keywords
Exercise ; Lifestyle Modification ; Nafld ; Nutrition ; Physical Activity ; Weight Loss; Fatty-liver-disease; Fructose Corn Syrup; Mediterranean Diet; Hepatic Steatosis; Insulin Sensitivity; Physical-activity; Lipid-content; Weight-loss; Exercise; Resistance
Language
english
Publication Year
2019
HGF-reported in Year
2019
ISSN (print) / ISBN
1043-2760
e-ISSN
1879-3061
Quellenangaben
Volume: 30,
Issue: 10,
Pages: 701-709
Publisher
Elsevier
Publishing Place
84 Theobalds Rd, London Wc1x 8rr, England
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)
POF-Topic(s)
90000 - German Center for Diabetes Research
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502600-012
WOS ID
WOS:000489015300005
Scopus ID
85070557435
Erfassungsdatum
2019-09-19