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Non-invasive determination of murine placental and foetal functional parameters with multispectral optoacoustic tomography.
Light Sci. Appl. 8:71 (2019)
Despite the importance of placental function in embryonic development, it remains poorly understood and challenging to characterize, primarily due to the lack of non-invasive imaging tools capable of monitoring placental and foetal oxygenation and perfusion parameters during pregnancy. We developed an optoacoustic tomography approach for real-time imaging through entire ~4 cm cross-sections of pregnant mice. Functional changes in both maternal and embryo regions were studied at different gestation days when subjected to an oxygen breathing challenge and perfusion with indocyanine green. Structural phenotyping of the cross-sectional scans highlighted different internal organs, whereas multi-wavelength acquisitions enabled non-invasive label-free spectroscopic assessment of blood-oxygenation parameters in foeto-placental regions, rendering a strong correlation with the amount of oxygen administered. Likewise, the placental function in protecting the embryo from extrinsically administered agents was substantiated. The proposed methodology may potentially further serve as a probing mechanism to appraise embryo development during pregnancy in the clinical setting.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Biophotonics ; Imaging And Sensing ; Photoacoustics; In-vivo; Bold Mri; Oxygenation; Visualization; Model; Angiography; Ultrasound; Tissue; Sheep
ISSN (print) / ISBN
2047-7538
e-ISSN
2047-7538
Journal
Light: Science & Applications
Quellenangaben
Volume: 8,
Issue: 1,
Article Number: 71
Publisher
Nature Publishing Group
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)