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Open Access Green as soon as Postprint is submitted to ZB.
Optical features of human skin revealed by optoacoustic mesoscopy in the visible and short-wave infrared regions.
Opt. Lett. 44, 4119-4122 (2019)
Detailed assessment of skin conditions or the efficacy of skin treatments could greatly benefit from noninvasively assessing the distribution of cutaneous and subcutaneous structures and biomolecules. We considered ultrawideband raster scan optoacoustic mesoscopy with an extended wavelength range from visible to short-wave infrared and observed previously unseen high-resolution images of lipids colocalized with water, melanin, and hemoglobin distribution in human skin. Based on this contrast, the technique resolves subcutaneous fat, the pilosebaceous unit with complete hair strand and bulb, dermal microvasculature, and epidermal structures. We further visualize melanoidins that form via the Maillard reaction in the ultrathin stratum corneum layer, analyze their absorption spectrum, and separate them from the melanin layer. The suggested method may allow novel interrogation of skin conditions, possibly impacting diagnostics and medical and cosmetic treatments.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Adipose-tissue
ISSN (print) / ISBN
0146-9592
e-ISSN
1539-4794
Journal
Optics Letters
Quellenangaben
Volume: 44,
Issue: 17,
Pages: 4119-4122
Publisher
Optical Society of America (OSA)
Publishing Place
2010 Massachusetts Ave Nw, Washington, Dc 20036 Usa
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)