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O'Connor, T. ; Zhou, X.* ; Kosla, J. ; Adili, A. ; Garcia Beccaria, M.* ; Kotsiliti, E. ; Pfister, D. ; Johlke, A.-L. ; Sinha, A.* ; Sankowski, R.* ; Schick, M.* ; Lewis, R.* ; Dokalis, N.* ; Seubert, B. ; Höchst, B.* ; Inverso, D.* ; Heide, D.* ; Zhang, W.* ; Weihrich, P.* ; Manske, K.* ; Wohlleber, D.* ; Anton, M.* ; Hoellein, A.* ; Seleznik, G.M.* ; Bremer, J.* ; Bleul, S.* ; Augustin, H.G.* ; Scherer, F.* ; Koedel, U.* ; Weber, A.* ; Protzer, U. ; Förster, R.* ; Wirth, T.* ; Aguzzi, A.* ; Meissner, F.* ; Prinz, M.* ; Baumann, B.* ; Höpken, U.E.* ; Knolle, P.A.* ; von Baumgarten, L.* ; Keller, U.* ; Heikenwälder, M.

Age-related gliosis promotes central nervous system lymphoma through CCL19-mediated tumor cell retention.

Cancer Cell 36, 250-267.e9 (2019)
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Open Access Green as soon as Postprint is submitted to ZB.
How lymphoma cells (LCs) invade the brain during the development of central nervous system lymphoma (CNSL) is unclear. We found that NF-κB-induced gliosis promotes CNSL in immunocompetent mice. Gliosis elevated cell-adhesion molecules, which increased LCs in the brain but was insufficient to induce CNSL. Astrocyte-derived CCL19 was required for gliosis-induced CNSL. Deleting CCL19 in mice or CCR7 from LCs abrogated CNSL development. Two-photon microscopy revealed LCs transiently entering normal brain parenchyma. Astrocytic CCL19 enhanced parenchymal CNS retention of LCs, thereby promoting CNSL formation. Aged, gliotic wild-type mice were more susceptible to forming CNSL than young wild-type mice, and astrocytic CCL19 was observed in both human gliosis and CNSL. Therefore, CCL19-CCR7 interactions may underlie an increased age-related risk for CNSL.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Ccl19 ; Cnsl ; Cxcl12 ; Dlbcl ; Gliosis ; Lymphoma ; Metastasis ; Neuroinflammation ; Pcnsl ; Scnsl
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 1535-6108
e-ISSN 1878-3686
Journal Cancer Cell
Quellenangaben Volume: 36, Issue: 3, Pages: 250-267.e9 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place Cambridge, Mass.
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)
POF-Topic(s) 30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-502700-003
G-551600-001
DOI 10.1016/j.ccell.2019.08.001
Scopus ID 85071313341
Erfassungsdatum 2019-09-30
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