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Loeffler, D. ; Wehling, A.* ; Schneiter, F.* ; Zhang, Y.* ; Müller-Bötticher, N.* ; Hoppe, P.S. ; Hilsenbeck, O. ; Kokkaliaris, K.D. ; Endele, M. ; Schroeder, T.

Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells.

Nature 573, 426-429 (2019)
Postprint DOI PMC
Open Access Green
Haematopoietic stem cells self-renew and differentiate into all blood lineages throughout life, and can repair damaged blood systems upon transplantation. Asymmetric cell division has previously been suspected to be a regulator of haematopoietic-stem-cell fate, but its existence has not directly been shown(1). In asymmetric cell division, asymmetric fates of future daughter cells are prospectively determined by a mechanism that is linked to mitosis. This can be mediated by asymmetric inheritance of cell-extrinsic niche signals by, for example, orienting the divisional plane, or by the asymmetric inheritance of cell-intrinsic fate determinants. Observations of asymmetric inheritance or of asymmetric daughter-cell fates alone are not sufficient to demonstrate asymmetric cell division(2). In both cases, sister-cell fates could be controlled by mechanisms that are independent of division. Here we demonstrate that the cellular degradative machinery-including lysosomes, autophagosomes, mitophagosomes and the protein NUMB-can be asymmetrically inherited into haematopoietic-stem-cell daughter cells. This asymmetric inheritance predicts the asymmetric future metabolic and translational activation and fates of haematopoietic-stem-cell daughter cells and their offspring. Therefore, our studies provide evidence for the existence of asymmetric cell division in haematopoietic stem cells.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Self-renewal; Division; Protein; Mouse; Quantification; Expression
ISSN (print) / ISBN 0028-0836
e-ISSN 1476-4687
Journal Nature
Quellenangaben Volume: 573, Issue: 7774, Pages: 426-429 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Stem Cell Dynamics (SCD)