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Roth, R. ; Lynch, K.* ; Hyoty, H.* ; Lönnrot, M.* ; Driscoll, K.A.* ; Johnson, S.B.* ; TEDDY Study Group (Ziegler, A.-G. ; Beyerlein, A. ; Hummel, M. ; Hummel, S. ; Janz, N. ; Knopff, A. ; Peplow, C. ; Scholz, M. ; Stock, J. ; Warncke, K. ; Wendel, L. ; Winkler, C.)

The association between stressful life events and respiratory infections during the first 4 years of life: The Environmental Determinants of Diabetes in the Young study.

Stress and Health 35, 289-303 (2019)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
The aim of this study was to conduct a prospective analysis of the association between negative life events (NLEs) and respiratory infections in children genetically at risk for islet autoimmunity (IA) and type 1 diabetes (T1D). Long- and short-term temporal associations between NLEs and rate of respiratory infection episodes (RIEs) in 5,618 children in The Environmental Determinants of Diabetes in the Young study for at least 1 up to 4 years were analysed. All models were adjusted for demographic, day care, season of infection, and psychosocial factors associated with the rate of child RIEs between study visits. The rate of child RIEs was 26% higher in Europe (Sweden, Finland, Germany) than in the United States (rate ratio [RR] = 1.26, p < 0.001). However, the percentage of child NLEs (odds ratio [OR] = 1.18, p < 0.001) and mother NLEs (OR = 1.83, p < 0.001) was higher in the United States compared with Europe. In both continents (Europe, RR = 1.12, p < 0.001; United States, RR = 1.07, p = 0.006), high child cumulative NLEs (>1 NLE per year since study inception) was significantly associated with an increased rate of child RIEs. This large-scale prospective study confirms observations that stress may increase the susceptibility for infections in paediatric populations and suggests at least one mechanism by which stress could increase risk for IA and T1D in genetically at risk children.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Autoimmunity ; Longitudinal Study ; Negative Life Events ; Respiratory Childhood Infections ; Stress ; Type 1 Diabetes; Psychological Stress; Psychosocial Stress; Islet Autoimmunity; Tract Infections; Smoke Exposure; Child Health; Risk-factors; Type-1; Illness; Pathogenesis
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 1532-3005
e-ISSN 1532-2998
Journal Stress and health
Quellenangaben Volume: 35, Issue: 3, Pages: 289-303 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Chichester [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research (IDF)
POF-Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502100-001
G-501900-211
G-501900-021
DOI 10.1002/smi.2861
WOS ID WOS:000482964700005
Erfassungsdatum 2019-09-23
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