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Kappler, L.* ; Lehmann, R.

Mass-spectrometric multi-omics linked to function - State-of-the-art investigations of mitochondria in systems medicine.

Trends Analyt. Chem. 119:115635 (2019)

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	Open Access Gold (Paid Option)

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Multi-omics applications are essential tools in systems medicine and biology. Alterations in molecular fingerprints are closely related to changes in cellular and subcellular function, but a linkage of functional investigations and omics analyses is quite rare. In mitochondria, lipids, proteins and post-translational modifications thereof are directly linked to function but also to structure. However, the complementary combination of multi-omics analyses and functional investigations in mitochondrial research is challenging. Analytical chemists can implement this strategy in systems medicine projects, thereby providing comprehensive results as a base for correct data interpretation and a deeper understanding of the role of mitochondria in health and disease. In this review we will discuss state-of-the-art approaches of this multistep process focussing on analytical, but also pre-analytical aspects, like mitochondrial purification and sample quality control, as joint key for valid functional multi-omics investigations of mitochondria by complementary lipidomics, proteomics and respiratory analyses. (C) 2019 The Authors. Published by Elsevier B.V.

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Multi-omics ; Mitochondria ; Lipidomics ; Proteomics ; Respirometry ; Mass Spectrometry ; Purification ; Systems Medicine; Liquid-chromatography; Shotgun Lipidomics; Metabolomics; Extraction; Biomarkers; Proteomics; Lipids

ISSN (print) / ISBN 0165-9936

e-ISSN 1873-3689

Journal TrAC Trends in Analytical Chemistry

Quellenangaben Volume: 119, Article Number: 115635

Publisher Elsevier

Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)