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Der Insulinrezeptor in Aktion — wie Insulin seinen Rezeptor aktiviert.
BioSpektrum 25, 485-487 (2019)
A fundamental question in signal transduction remains how the insulin receptor transmits signals upon ligand binding across the membrane. The overall architecture of the intact insulin receptor and its mode of activation have been controversially debated. Using a reconstitution approach, we were able to visualize the membrane-embedded full-length insulin receptors by electron microscopy demonstrating its activation mechanism.
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Publication type
Article: Journal article
Document type
Comment, Opinion
Language
english
Publication Year
2019
HGF-reported in Year
2019
ISSN (print) / ISBN
0947-0867
e-ISSN
1868-6249
Journal
BioSpektrum
Quellenangaben
Volume: 25,
Issue: 5,
Pages: 485-487
Publisher
Springer
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)
POF-Topic(s)
90000 - German Center for Diabetes Research
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502600-002
Scopus ID
85071886187
Erfassungsdatum
2019-10-08