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Mokrousov, M.D.* ; Novoselova, M.* ; Nolan, J.* ; Harrington, W.* ; Rudakovskaya, P.* ; Bratashov, D.N.* ; Galanzha, E.* ; Fuenzalida Werner, J.P. ; Yakimov, B.P.* ; Nazarikov, G.* ; Drachev, V.P.* ; Shirshin, E.A.* ; Ntziachristos, V. ; Stiel, A.-C. ; Zharov, V.P.* ; Gorin, D.A.*

Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green.

Biomed. Opt. Express 10, 4775-4788 (2019)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
A new type of bimodal contrast agent was made that is based on the self-quenching of indocyanine green (ICG) encapsulated in a biocompatible and biodegradable polymer shell. The increasing of a local ICG concentration that is necessary for the obtaining of self-quenching effect was achieved by freezing-induced loading and layer-by-layer assembly. As a result, an efficient photoacoustic(optoacoustic)/fluorescent contrast agent based on composite indocyanine green/polymer particles was successfully prepared and was characterized by fluorescence and photoacoustic(optoacoustic) tomography in vitro. This type of contrast agent holds good promise for clinical application owing to its high efficiency and biosafety.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Photodynamic Therapy; Nanoparticles; Enhancement; Distance
ISSN (print) / ISBN 2156-7085
e-ISSN 2156-7085
Journal Biomedical Optics Express
Quellenangaben Volume: 10, Issue: 9, Pages: 4775-4788 Article Number: , Supplement: ,
Publisher Optical Society of America (OSA)
Publishing Place 2010 Massachusetts Ave Nw, Washington, Dc 20036 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)