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Littrell, O.M.* ; Stoeger, C. ; Maier, H. ; Fuchs, H. ; Cassis, L.A.* ; Gerhardt, G.A.* ; Grondin, R.* ; Gailus-Durner, V.

Costs of implementing quality in research practice.

In:. Berlin ; Heidelberg: Springer, 2019. 399-423 (Handb. Exp. Pharmacol. ; 257)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Using standardized guidelines in preclinical research has received increased interest in light of recent concerns about transparency in data reporting and apparent variation in data quality, as evidenced by irreproducibility of results. Although the costs associated with supporting quality through a quality management system are often obvious line items in laboratory budgets, the treatment of the costs associated with quality failure is often overlooked and difficult to quantify. Thus, general estimations of quality costs can be misleading and inaccurate, effectively undervaluing costs recovered by reducing quality defects. Here, we provide examples of quality costs in preclinical research and describe how we have addressed misconceptions of quality management implementation as only marginally beneficial and/or unduly burdensome. We provide two examples of implementing a quality management system (QMS) in preclinical experimental (animal) research environments – one in Europe, the German Mouse Clinic, having established ISO 9001 and the other in the United States, the University of Kentucky (UK), having established Good Laboratory Practice-compliant infrastructure. We present a summary of benefits to having an effective QMS, as may be useful in guiding discussions with funders or administrators to promote interest and investment in a QMS, which ultimately supports shared, mutually beneficial outcomes.
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Publication type Article: Edited volume or book chapter
Corresponding Author
Keywords Automation ; Cost Of Quality (coq) ; Documentation ; German Mouse Clinic (gmc) ; Good Laboratory Practice (glp) ; Iso 9001 ; Quality Management System (qms) ; Reproducibility
ISSN (print) / ISBN 0171-2004
Journal Handbook of Experimental Pharmacology
Quellenangaben Volume: 257, Issue: , Pages: 399-423 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Berlin ; Heidelberg
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)