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Extracellular matrix remodeling of adipose Ttssue in obesity and metabolic diseases.
Int. J. Mol. Sci. 20:4888 (2019)
The extracellular matrix (ECM) is a network of different proteins and proteoglycans that controls differentiation, migration, repair, survival, and development, and it seems that its remodeling is required for healthy adipose tissue expansion. Obesity drives an excessive lipid accumulation in adipocytes, which provokes immune cells infiltration, fibrosis (an excess of deposition of ECM components such as collagens, elastin, and fibronectin) and inflammation, considered a consequence of local hypoxia, and ultimately insulin resistance. To understand the mechanism of this process is a challenge to treat the metabolic diseases. This review is focused at identifying the putative role of ECM in adipose tissue, describing its structure and components, its main tissue receptors, and how it is affected in obesity, and subsequently the importance of an appropriate ECM remodeling in adipose tissue expansion to prevent metabolic diseases.
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Publication type
Article: Journal article
Document type
Review
Keywords
Obesity ; Adipose Tissue ; Extracellular Matrix ; Insulin Resistance; Fatty Liver-disease; Muscle Insulin-resistance; Diet-induced Obesity; Body-mass Index; Differential Expression; Therapeutic Targets; Lipid-metabolism; Vascular-disease; Adipocyte Number; Potential Role
ISSN (print) / ISBN
1422-0067
e-ISSN
1661-6596
Quellenangaben
Volume: 20,
Issue: 19,
Article Number: 4888
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)