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Open Access Green as soon as Postprint is submitted to ZB.
Ferroptose: Tod durch Eisenabhängige Lipidperoxidation.
BioSpektrum 25, 614-616 (2019)
Ferroptosis is an oxidative form of necrotic cell death highly relevant for many degenerative diseases and cancer. Ferroptosis is marked by iron-dependent lipid peroxidation and is distinct from other cell death modalities. Glutathione peroxidase 4 is the key ferroptosis player as it efficiently controls lipid peroxidation. Transgenic mice and animal models of disease have shown which cells and tissues are prone to undergo ferroptosis. The discovery of novel ferroptosis inhibitors and inducers thus offers the great potential in the development of innovative drugs to treat yet incurable diseases.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
german
Publication Year
2019
HGF-reported in Year
2019
ISSN (print) / ISBN
0947-0867
e-ISSN
1868-6249
Journal
BioSpektrum
Quellenangaben
Volume: 25,
Issue: 6,
Pages: 614-616
Publisher
Springer
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-500500-001
Scopus ID
85073075460
Erfassungsdatum
2019-10-21