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Ferroptose: Tod durch Eisenabhängige Lipidperoxidation.

BioSpektrum 25, 614-616 (2019)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Ferroptosis is an oxidative form of necrotic cell death highly relevant for many degenerative diseases and cancer. Ferroptosis is marked by iron-dependent lipid peroxidation and is distinct from other cell death modalities. Glutathione peroxidase 4 is the key ferroptosis player as it efficiently controls lipid peroxidation. Transgenic mice and animal models of disease have shown which cells and tissues are prone to undergo ferroptosis. The discovery of novel ferroptosis inhibitors and inducers thus offers the great potential in the development of innovative drugs to treat yet incurable diseases.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0947-0867
e-ISSN 1868-6249
Journal BioSpektrum
Quellenangaben Volume: 25, Issue: 6, Pages: 614-616 Article Number: , Supplement: ,
Publisher Springer
Non-patent literature Publications
Reviewing status Peer reviewed