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Kleinert, M. ; Sachs, S. ; Habegger, K.M.* ; Hofmann, S.M. ; Müller, T.D.

Glucagon regulation of energy expenditure.

Int. J. Mol. Sci. 20:5407 (2019)
Publ. Version/Full Text DOI PMC
Open Access Gold
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Glucagon's ability to increase energy expenditure has been known for more than 60 years, yet the mechanisms underlining glucagon's thermogenic effect still remain largely elusive. Over the last years, significant efforts were directed to unravel the physiological and cellular underpinnings of how glucagon regulates energy expenditure. In this review, we summarize the current knowledge on how glucagon regulates systems metabolism with a special emphasis on its acute and chronic thermogenic effects.
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Publication type Article: Journal article
Document type Review
Keywords Glucagon ; Obesity ; Energy Expenditure ; Fgf21 ; Brown Adipose Tissue ; Pharmacology; Brown Adipose-tissue; Stress Hormone Infusion; Receptor Antagonist; Metabolic-response; Lipolytic Hormones; Glucose-production; Injected Glucagon; High-protein; Food-intake; Growth
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 1661-6596
e-ISSN 1422-0067
Quellenangaben Volume: 20, Issue: 21, Pages: , Article Number: 5407 Supplement: ,
Publisher MDPI
Publishing Place Basel
Reviewing status Peer reviewed
POF-Topic(s) 90000 - German Center for Diabetes Research
30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-221
G-502200-001
G-502390-001
Scopus ID 85074370668
PubMed ID 31671603
Erfassungsdatum 2019-11-11