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Alexander, H.* ; Paller, A.S.* ; Traidl-Hoffmann, C. ; Beck, L.A.* ; de Benedetto, A.* ; Dhar, S.* ; Girolomoni, G.* ; Irvine, A.D.* ; Spuls, P.* ; Su, J.* ; Thyssen, J.P.* ; Vestergaard, C.* ; Werfel, T.* ; Wollenberg, A.* ; Deleuran, M.* ; Flohr, C.*

The role of bacterial skin infections in atopic dermatitis: Expert statement and review from the International Eczema Council Skin Infection Group.

Br. J. Dermatol. 182, 1331-1342 (2019)
Publ. Version/Full Text Postprint DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Patients with atopic dermatitis (AD) have an increased risk of bacterial skin infections, which cause significant morbidity and, if untreated, may become systemic. Staphylococcus aureus colonizes the skin of most patients with AD and is the most common organism to cause infections. Overt bacterial infection is easily recognized by the appearance of weeping lesions, honey-coloured crusts and pustules. However, the wide variability in clinical presentation of bacterial infection in AD and the inherent features of AD – cutaneous erythema and warmth, oozing associated with oedema, and regional lymphadenopathy – overlap with those of infection, making clinical diagnosis challenging. Furthermore, some features may be masked because of anatomical site- and skin-type-specific features, and the high frequency of S. aureus colonization in AD makes positive skin swab culture of suspected infection unreliable as a diagnostic tool. The host mechanisms and microbial virulence factors that underlie S. aureus colonization and infection in AD are incompletely understood. The aim of this article is to present the latest evidence from animal and human studies, including recent microbiome research, to define the clinical features of bacterial infections in AD, and to summarize our current understanding of the host and bacterial factors that influence microbial colonization and virulence.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Resistant Staphylococcus-aureus; Innate Immune-response; Methicillin-resistant; Topical Corticosteroids; Antimicrobial Peptides; Filaggrin Expression; Systemic Infections; Clinical-features; Cytokine Milieu; Increased Risk
ISSN (print) / ISBN 0007-0963
e-ISSN 1365-2133
Journal British Journal of Dermatology - BJD
Quellenangaben Volume: 182, Issue: 6, Pages: 1331-1342 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Environmental Medicine (IEM)