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Open Access Green as soon as Postprint is submitted to ZB.
High resolution 3D imaging of primary and secondary tumor spheroids using multicolor multi-angle Light Sheet Fluorescence Microscopy (LSFM).
Proc. SPIE 11076, DOI: 10.1117/12.2527214 (2019)
Breast cancer and Glioblastoma brain cancer are aggressive malignancies with poor prognosis. In this study primary Glioblastoma and secondary breast cancer spheroids are formed and treated with the well-known Temozolomide and Doxorubicin chemotherapeutics, respectively. A custom multi-angle Light Sheet Fluorescence Microscope is employed for high resolution imaging of both cancer cell spheroids. Such a technique is successful in realizing pre-clinical drug screening, while enables the discrimination among physiologic tumor parameters. LSFM technique, parameters and method followed are also presented.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Breast Cancer ; Drug Screening And Individualized Therapy ; Glioblastoma Brain Cancer ; Light Sheet Fluorescence Microscopy (lsfm) ; Multicellular Tumor Spheroids (mcts)
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
Journal
Proceedings of SPIE
Quellenangaben
Volume: 11076
Publisher
SPIE
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)