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High resolution 3D imaging of primary and secondary tumor spheroids using multicolor multi-angle Light Sheet Fluorescence Microscopy (LSFM).
Proc. SPIE 11076, DOI: 10.1117/12.2527214 (2019)
Publ. Version/Full Text
DOI
Breast cancer and Glioblastoma brain cancer are aggressive malignancies with poor prognosis. In this study primary Glioblastoma and secondary breast cancer spheroids are formed and treated with the well-known Temozolomide and Doxorubicin chemotherapeutics, respectively. A custom multi-angle Light Sheet Fluorescence Microscope is employed for high resolution imaging of both cancer cell spheroids. Such a technique is successful in realizing pre-clinical drug screening, while enables the discrimination among physiologic tumor parameters. LSFM technique, parameters and method followed are also presented.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Breast Cancer ; Drug Screening And Individualized Therapy ; Glioblastoma Brain Cancer ; Light Sheet Fluorescence Microscopy (lsfm) ; Multicellular Tumor Spheroids (mcts)
Language
english
Publication Year
2019
HGF-reported in Year
2019
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
Journal
Proceedings of SPIE
Quellenangaben
Volume: 11076
Publisher
SPIE
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-505500-001
Scopus ID
85084482509
Scopus ID
85074296303
Erfassungsdatum
2019-11-11