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Advances in optoacoustic neurotomography of animal models.
Trends Biotechnol. 37, 1315-1326 (2019)
Unlike traditional optical methods, optoacoustic imaging is less sensitive to scattering of ballistic photons, so it is capable of high-resolution interrogation at a greater depth. By integrating video-rate visualization with multiplexing and sensing a range of endogenous and exogenous chromophores, optoacoustic imaging has matured into a versatile noninvasive investigation modality with rapidly expanding use in biomedical research. We review the principal features of the technology and discuss recent advances it has enabled in structural, functional, and molecular neuroimaging in small-animal models. In extending the boundaries of noninvasive observation beyond the reach of customary photonic methods, the latest developments in optoacoustics have substantially advanced neuroimaging inquiry, with promising implications for basic and translational studies.
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Publication type
Article: Journal article
Document type
Review
Keywords
Hemodynamic Response ; Msot ; Neuroimaging ; Noninvasive Interrogation ; Photoacoustic; Photoacoustic Tomography; Blood Oxygenation; Mouse Model; Amyloid Plaques; Neural Activity; Resolution; Microscopy; Brain; Deep; Visualization
ISSN (print) / ISBN
0167-7799
e-ISSN
1879-3096
Journal
Trends in Biotechnology
Quellenangaben
Volume: 37,
Issue: 12,
Pages: 1315-1326
Publisher
Elsevier
Publishing Place
84 Theobalds Rd, London Wc1x 8rr, England
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)