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Sepúlveda-Loyola, W.* ; Phu, S.* ; Bani Hassan, E.* ; Brennan-Olsen, S.L.* ; Zanker, J.* ; Vogrin, S.* ; Conzade, R. ; Kirk, B.* ; Al Saedi, A.* ; Probst, V.* ; Duque, G.*

The joint occurrence of osteoporosis and sarcopenia (Osteosarcopenia): Definitions and characteristics.

J. Am. Med. Dir. Assoc. 21, 220-225 (2020)

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Open Access Green as soon as Postprint is submitted to ZB.

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Objectives: We sought to examine the associations of osteosarcopenia with physical performance, balance, and falls and fractures in community-dwelling older adults. Additionally, we aimed to determine which clinical outcomes are associated with specific components of osteosarcopenia.Design: Cross-sectional study.Setting and Participants: 253 participants (77% women; aged 77.9 +/- 0.42 years) who presented for a falls and fractures risk assessment in Melbourne, Australia.Methods: Participants were mobile, community-dwelling older adults (>= 65 years) free of cognitive impairment. Body composition (via dual-energy x-ray absorptiometry), physical performance [via Timed Up and Go (TUG) and Short Physical Performance Battery (SPPB)], and balance [via Four-Square Step test (FSS) and posturography] were examined. Falls in the past year and fractures in the past 5 years were self-reported. Osteosarcopenia was defined as (1) low bone mineral density (BMD) [T score <-1 standard deviation (SD)] combined with sarcopenia and (2) osteoporosis (BMD T score <=-2.5 SD) combined with severe sarcopenia. For sarcopenia, we employed the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP1), the revised criteria (EWGSOP2), and that of the Foundation for the National Institutes for Health (FNIH). Kruskal-Wallis and logistic regression tests were used for statistical analysis.Results: Osteosarcopenia was associated with worse SPPB, TUG, FSS, limit of stability, and falls and fractures history. Additionally, osteosarcopenia (using the severe sarcopenia classification) conferred an increased rate of falls [odds ratios (ORs) from 2.83 to 3.63; P < .05 for all] and fractures (ORs from 3.86 to 4.38; P < .05 for all) when employing the EWGSOP2 and FNIH definitions, respectively.Conclusions and Implications: Compared with the nonosteosarcopenic group, those with osteosarcopenia had greater impairment of physical performance and balance. The EWGSOP2 and FNIH criteria resulted in the strongest associations with physical performance and self-reported falls and fractures.

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