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Expression and phase separation potential of heterochromatin proteins during early mouse development.
EMBO Rep. 20:e47952 (2019)
In most eukaryotes, constitutive heterochromatin is associated with H3K9me3 and HP1 alpha. The latter has been shown to play a role in heterochromatin formation through liquid-liquid phase separation. However, many other proteins are known to regulate and/or interact with constitutive heterochromatic regions in several species. We postulate that some of these heterochromatic proteins may play a role in the regulation of heterochromatin formation by liquid-liquid phase separation. Indeed, an analysis of the constitutive heterochromatin proteome shows that proteins associated with constitutive heterochromatin are significantly more disordered than a random set or a full nucleome set of proteins. Interestingly, their expression begins low and increases during preimplantation development. These observations suggest that the preimplantation embryo is a useful model to address the potential role for phase separation in heterochromatin formation, anticipating exciting research in the years to come.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Development ; Epigenetics ; Heterochromatin Establishment ; Phase Separation; Histone H3; Complex Coacervation; Chromatin-structure; Rna-binding; Lysine 9; Liquid; Sequence; Domains; Methylation; Hp1-alpha
ISSN (print) / ISBN
1469-221X
e-ISSN
1469-3178
Journal
EMBO Reports
Quellenangaben
Volume: 20,
Issue: 12,
Article Number: e47952
Publisher
EMBO Press
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epigenetics and Stem Cells (IES)