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Noordam, R.* ; Bos, M.M.* ; Wang, H.* ; Winkler, T.W.* ; Bentley, A.R.* ; Kilpeläinen, T.O.* ; de Vries, P.S.* ; Sung, Y.J.* ; Schwander, K.* ; Cade, B.E.* ; Manning, A.* ; Aschard, H.* ; Brown, M.R.* ; Chen, H.* ; Franceschini, N.* ; Musani, S.K.* ; Richard, M.* ; Vojinovic, D.* ; Aslibekyan, S.* ; Bartz, T.M.* ; de Las Fuentes, L.* ; Feitosa, M.* ; Horimoto, A.R.* ; Ilkov, M.* ; Kho, M.* ; Kraja, A.* ; Li, C.* ; Lim, E.* ; Liu, Y.* ; Mook-Kanamori, D.O.* ; Rankinen, T.* ; Tajuddin, S.M.* ; van der Spek, A.* ; Wang, Z.* ; Marten, J.* ; Laville, V.* ; Alver, M.* ; Evangelou, E.* ; Graff, M.E.* ; He, M.* ; Kühnel, B. ; Lyytikäinen, L.P.* ; Marques-Vidal, P.* ; Nolte, I.M.* ; Palmer, N.D.* ; Rauramaa, R.* ; Shu, X.O.* ; Snieder, H.* ; Weiss, S.* ; Wen, W.* ; Yanek, L.R.* ; Adolfo, C.* ; Ballantyne, C.* ; Bielak, L.* ; Biermasz, N.R.* ; Boerwinkle, E.* ; Dimou, N.* ; Eiriksdottir, G.* ; Gao, C.* ; Gharib, S.A.* ; Gottlieb, D.J.* ; Haba-Rubio, J.* ; Harris, T.B.* ; Heikkinen, S.* ; Heinzer, R.* ; Hixson, J.E.* ; Homuth, G.* ; Ikram, M.A.* ; Komulainen, P.* ; Krieger, J.E.* ; Lee, J.* ; Liu, J.* ; Lohman, K.K.* ; Luik, A.I.* ; Mägi, R.* ; Martin, L.W.* ; Meitinger, T. ; Metspalu, A.* ; Milaneschi, Y.* ; Nalls, M.A.* ; O'Connell, J.* ; Peters, A. ; Peyser, P.* ; Raitakari, O.T.* ; Reiner, A.P.* ; Rensen, P.C.N.* ; Rice, T.K.* ; Rich, S.S.* ; Roenneberg, T.* ; Rotter, J.I.* ; Schreiner, P.J.* ; Shikany, J.* ; Sidney, S.S.* ; Sims, M.* ; Sitlani, C.M.* ; Sofer, T.* ; Strauch, K. ; Swertz, M.A.* ; Taylor, K.D.* ; Uitterlinden, A.G.* ; van Duijn, C.M.* ; Völzke, H.* ; Waldenberger, M. ; Wallance, R.B.* ; van Dijk, K.W.* ; Yu, C.* ; Zonderman, A.B.* ; Becker, D.M.* ; Elliott, P.* ; Esko, T.* ; Gieger, C. ; Grabe, H.J.* ; Lakka, T.A.* ; Lehtimäki, T.* ; North, K.E.* ; Penninx, B.W.J.H.* ; Vollenweider, P.* ; Wagenknecht, L.E.* ; Wu, T.* ; Xiang, Y.B.* ; Zheng, W.* ; Arnett, D.K.* ; Bouchard, C.* ; Evans, M.K.* ; Gudnason, V.* ; Kardia, S.* ; Kelly, T.N.* ; Kritchevsky, S.B.* ; Loos, R.J.F.* ; Pereira, A.C.* ; Province, M.* ; Psaty, B.M.* ; Rotimi, C.* ; Zhu, X.* ; Amin, N.* ; Cupples, L.A.* ; Fornage, M.* ; Fox, E.F.* ; Guo, X.* ; Gauderman, W.J.* ; Rice, K.* ; Kooperberg, C.* ; Munroe, P.B.* ; Liu, C.T.* ; Morrison, A.C.* ; Rao, D.C.* ; van Heemst, D.* ; Redline, S.*

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.

Nat. Commun. 10:5121 (2019)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Genome-wide Association; Coronary-heart-disease; Density-lipoprotein Cholesterol; Gene-environment Interaction; Gamma-glutamyl-transferase; Body-mass Index; Metabolic Syndrome; Diurnal Rhythm; Plasma-lipids; Risk
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 10, Issue: 1, Pages: , Article Number: 5121 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
Institute of Genetic Epidemiology (IGE)
POF-Topic(s) 30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504091-001
G-504091-004
G-500700-001
G-504000-001
G-504100-001
DOI 10.1038/s41467-019-12958-0
WOS ID WOS:000495858500002
Scopus ID 85074934485
PubMed ID 31719535
Erfassungsdatum 2019-11-26
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