Clues to quality of journals
Open Access Policy of Helmholtz Association 2016
CC Licencences
Publication Metrics
Home
Deutsch
New EVA Application
Advanced Search
Browse by ...
Publication overview
Statistics (last 5 years)
OA Publications
Submit Publication
Import publication from...
Report missing publication
Contact persons
Help
Text
Endnote (RIS)
BibTeX
DOI
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
Growth factor-dependent and -independent activation of mTORC2.
Trends Endocrinol. Metab. 31, 13-24 (2020)
The target of rapamycin complex 2 (TORC2) was discovered in 2002 in budding yeast. Its mammalian counterpart, mTORC2, was first described in 2004. Soon thereafter it was demonstrated that mTORC2 directly phosphorylates Akt on Ser473, ending a long search for the elusive 'second' insulin-responsive Akt kinase. In this review we discuss key evidence pertaining to the subcellular localization of mTORC2, highlighting a spatial heterogeneity that relates to mTORC2 activation. We summarize current models for how growth factors (GFs), such as insulin, trigger mTORC2 activation, and we provide a comprehensive discussion focusing on a new exciting frontier, the molecular mechanisms underpinning GF-independent activation of mTORC2.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
11.641
2.566
10
11
Annotations
Special Publikation
Hide on homepage
Publication type
Article: Journal article
Document type
Review
Keywords
Activation Mechanisms ; Exercise. ; Mtorc2 ; Subcellular Localization; Complex 2 Mtorc2; Mammalian Target; Glucose-uptake; Phosphatidic-acid; Membrane Localization; Protein Complexes; Phosphoinositide 3-kinase; Motif Phosphorylation; Endoplasmic-reticulum; Akt Phosphorylation
Language
english
Publication Year
2020
Prepublished in Year
2019
HGF-reported in Year
2019
ISSN (print) / ISBN
1043-2760
e-ISSN
1879-3061
Quellenangaben
Volume: 31,
Issue: 1,
Pages: 13-24
Publisher
Elsevier
Publishing Place
84 Theobalds Rd, London Wc1x 8rr, England
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)
POF-Topic(s)
30201 - Metabolic Health
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502200-001
WOS ID
WOS:000504047400003
Scopus ID
85074714733
Erfassungsdatum
2019-11-25