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Open Access Green as soon as Postprint is submitted to ZB.
Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions.
Neuroscience 159, 610-617 (2009)
Corticotropin-releasing hormone (CRH) coordinates neuroendocrine and behavioral adaptations to stress. Acute CRH administration in vivo activates extracellular signal-regulated kinase 1/2 (ERK1/2) in limbic brain areas, acting through the CRH receptor type 1 (CRH-R1). In the present study, we used CRH-COE-Cam mice that overexpress CRH in limbic-restricted areas, to analyze the effect of chronic CRH overexpression on ERK1/2 activation. By immunohistochemistry and confocal microscopy analysis we found that pERK1/2 levels in the basolateral amygdala (BLA) were similar in control and CRH overexpressing mice under basal conditions. Acute stress caused comparably increased levels of corticosterone in both control (CRH-COEcon-Cam) and CRH overexpressing (CRH-COEhom-Cam) animals. CRH-COEhom-Cam mice after stress showed reduced pERK1/2 immunoreactivity in the BLA compared to CRH-COEhom-Cam animals under basal conditions. Radioligand binding and in situ hybridization revealed higher density of CRH-R1 in the amygdala of CRH-COEhom mice under basal conditions compared to control littermates. A significant reduction of the receptor levels was observed in this area after acute stress, suggesting that stress may trigger CRH-R1 internalization/downregulation in these CRH overexpressing mice. Chronic CRH overexpression leads to reduced ERK1/2 activation in response to acute stress in the BLA.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
HPA axis; CRH; CRF; CRH receptor; ERK; activated protein-kinases; central-nervous-system; rat-brain; factor-receptor; map kinase; synaptic plasticity; transgenic mice; messenger-rnas; crf receptors; swim stress
Language
english
Publication Year
2009
HGF-reported in Year
2009
ISSN (print) / ISBN
0306-4522
e-ISSN
1873-7544
Journal
Neuroscience
Quellenangaben
Volume: 159,
Issue: 2,
Pages: 610-617
Publisher
International Brain Research Organization, Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)
POF-Topic(s)
30204 - Cell Programming and Repair
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-500500-001
G-520600-001
G-520600-001
Scopus ID
61349189527
PubMed ID
19361479
Erfassungsdatum
2009-07-09