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Fat and sugar-a dangerous duet. A comparative review on metabolic remodeling in rodent models of nonalcoholic fatty liver disease.
Nutrients 11:2871 (2019)
Nonalcoholic fatty liver disease (NAFLD) is a common disease in Western society and ranges from steatosis to steatohepatitis to end-stage liver disease such as cirrhosis and hepatocellular carcinoma. The molecular mechanisms that are involved in the progression of steatosis to more severe liver damage in patients are not fully understood. A deeper investigation of NAFLD pathogenesis is possible due to the many different animal models developed recently. In this review, we present a comparative overview of the most common dietary NAFLD rodent models with respect to their metabolic phenotype and morphological manifestation. Moreover, we describe similarities and controversies concerning the effect of NAFLD-inducing diets on mitochondria as well as mitochondria-derived oxidative stress in the progression of NAFLD.
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Publication type
Article: Journal article
Document type
Review
Keywords
Mitochondria ; Nafld-inducing Diets ; Nonalcoholic Fatty Liver Disease ; Oxidative Stress; Hepatic Insulin-resistance; Choline-deficient Diet; Type-2 Diabetes-mellitus; Antisense Oligonucleotide Inhibitors; Endoplasmic-reticulum Stress; Gamma-coactivator 1-alpha; Acetyl-coa Carboxylase-1; De-novo Lipogenesis; Protein-kinase-c; Oxidative Stress
ISSN (print) / ISBN
2072-6643
e-ISSN
2072-6643
Journal
Nutrients
Quellenangaben
Volume: 11,
Issue: 12,
Article Number: 2871
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed