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Simões, I.C.M.* ; Janikiewicz, J.* ; Bauer, J.* ; Karkucinska-Wieckowska, A.* ; Kalinowski, P.* ; Dobrzyń, A.* ; Wolski, A.* ; Pronicki, M.* ; Zieniewicz, K.* ; Dobrzyń, P.* ; Krawczyk, M.* ; Zischka, H. ; Wieckowski, M.R.* ; Potes, Y.*

Fat and sugar-a dangerous duet. A comparative review on metabolic remodeling in rodent models of nonalcoholic fatty liver disease.

Nutrients 11:2871 (2019)
Publ. Version/Full Text DOI PMC
Open Access Gold
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Nonalcoholic fatty liver disease (NAFLD) is a common disease in Western society and ranges from steatosis to steatohepatitis to end-stage liver disease such as cirrhosis and hepatocellular carcinoma. The molecular mechanisms that are involved in the progression of steatosis to more severe liver damage in patients are not fully understood. A deeper investigation of NAFLD pathogenesis is possible due to the many different animal models developed recently. In this review, we present a comparative overview of the most common dietary NAFLD rodent models with respect to their metabolic phenotype and morphological manifestation. Moreover, we describe similarities and controversies concerning the effect of NAFLD-inducing diets on mitochondria as well as mitochondria-derived oxidative stress in the progression of NAFLD.
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Publication type Article: Journal article
Document type Review
Keywords Mitochondria ; Nafld-inducing Diets ; Nonalcoholic Fatty Liver Disease ; Oxidative Stress; Hepatic Insulin-resistance; Choline-deficient Diet; Type-2 Diabetes-mellitus; Antisense Oligonucleotide Inhibitors; Endoplasmic-reticulum Stress; Gamma-coactivator 1-alpha; Acetyl-coa Carboxylase-1; De-novo Lipogenesis; Protein-kinase-c; Oxidative Stress
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 2072-6643
e-ISSN 2072-6643
Journal Nutrients
Quellenangaben Volume: 11, Issue: 12, Pages: , Article Number: 2871 Supplement: ,
Publisher MDPI
Publishing Place Basel
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Toxicology and Pharmacology (TOX)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505200-003
DOI 10.3390/nu11122871
WOS ID WOS:000506917800033
Scopus ID 85075535785
PubMed ID 31771244
Erfassungsdatum 2019-12-02
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