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Muri, J.* ; Thut, H.* ; Bornkamm, G.W. ; Kopf, M.*

B1 and marginal zone B cells but not follicular B2 cells require Gpx4 to prevent lipid peroxidation and ferroptosis.

Cell Rep. 29, 2731-2744.e4 (2019)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
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Aerobic organisms need to maintain cellular redox homeostasis. Glutathione peroxidase-4 (Gpx4) has the unique ability to protect cells against lipid peroxidation. Here, we show that Gpx4 is absolutely required to prevent ferroptosis during development, maintenance, and responses of innate-like B cells, namely, the B1 and marginal zone (MZ) B cells. In contrast, Gpx4 is dispensable for the development, germinal center reactions, and antibody responses of follicular B2 cells. Mechanistically, we show increased lipid metabolism and sensitivity to lipid peroxidation and ferroptosis in B1 and MZ B cells compared to follicular B2 cells, consistent with the requirement of Gpx4 in innate-like B cells. This high sensitivity to ferroptosis of innate-like B cells may be used to therapeutically target Gpx4 in certain forms of B cell malignancies involving B1 cells.
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Publication type Article: Journal article
Document type Scientific Article
Keywords B Cell Immunometabolism ; B1 Cells ; Fatty-acid Metabolism ; Ferroptosis ; Glutathione ; Gpx4 ; Lipid Ros ; Marginal Zone B Cells ; Redox System; Hydroperoxide Glutathione-peroxidase; Oxidative Stress; Metabolism; Regulator; Dna; Differentiation; Homeostasis; Biology; Damage; Ros
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Journal Cell Reports
Quellenangaben Volume: 29, Issue: 9, Pages: 2731-2744.e4 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-501490-001
DOI 10.1016/j.celrep.2019.10.070
WOS ID WOS:000499377000018
Scopus ID 85075520365
PubMed ID 31775041
Erfassungsdatum 2019-12-04
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