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Comprehensive analysis of the Alternaria mycobolome using mass spectrometry based metabolomics.
Mol. Nutr. Food Res. 64:1900558 (2020)
Scope Alternaria fungi are widely distributed plant pathogens infecting grains and vegetables and causing major harvest losses in the field and during postharvest storage. Besides, consumers are endangered by the formation of toxic secondary metabolites. Some of these secondary metabolites are chemically characterized as mycotoxins, but the majority of the Alternaria mycobolome still remains unknown. Methods and results Fourier-transform ion cyclotron resonance mass spectrometry (FTICR-MS) and LC-MS/MS are combined for the non-targeted and targeted analysis of the metabolome of three A. alternata isolates and one A. solani isolate. Due to the ultra-high resolution of FTICR-MS, unique molecular formulae are assigned to measured m/z signals. The molecular formulae are matched to entries of the databases Antibase and Kyoto Encyclopedia of Genes and Genomes. The non-targeted analysis of the fungal extracts reveals variations in the secondary metabolite profile of A. alternata and A. solani. Differences in the biosynthesis of dibenzo-alpha-pyrones, perylene quinones, tentoxin, and tenuazonic acid of the A. alternata and A. solani isolates are determined applying targeted LC-MS/MS. Conclusion FTICR-MS analyses reveal clear differences in the metabolic profile of the A. solani and the A. alternata isolates.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Alternaria Alternata ; Alterperylenepoxide A-9-mercaptolactate ; Fourier Transform Ion Cyclotron Resonance Mass Spectrometry ; Non-targeted Metabolomics ; Ultra-high Resolution; (8r,9s)-9,10-epoxy-8-hydroxy-9-methyl-deca-(2e,4z,6e)-trienoic Acid; Masked Mycotoxins; Altertoxin-ii; Methyl-ether; Metabolites; Toxins; Biosynthesis; Fungus; Dihydrotentoxin; Classification
Language
english
Publication Year
2020
Prepublished in Year
2019
HGF-reported in Year
2019
ISSN (print) / ISBN
1613-4125
e-ISSN
1613-4133
Quellenangaben
Volume: 64,
Issue: 3,
Article Number: 1900558
Publisher
Wiley
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status
Peer reviewed
Institute(s)
Research Unit BioGeoChemistry and Analytics (BGC)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Environmental Sciences
PSP Element(s)
G-504800-001
WOS ID
WOS:000506382500001
Scopus ID
85077906110
PubMed ID
31802615
Erfassungsdatum
2019-12-10