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as soon as is submitted to ZB.
Use of microtubule stabilizing compounds for the treatment of lesions of CNS axons..
Schutzrecht EP1700596A1 (2005)
The present invention provides a use of one or more microtubule
stabilizing compounds for the preparation of a pharmaceutical
composition for the treatment of lesions of CNS axons wherein the
pharmaceutical composition is administered locally directly into the
lesion or immediately adjacent thereto, whereby the one or more
compound(s) is/are selected from the group consisting of taxanes,
epothilones, laulimalides, sesquiterpene lactones, sarcodictyins,
diterpenoids, peloruside A, discodermolide, dicoumarol, ferulenol,
NSC12983, taccalonolide A, taccalonolide E, Rhazinilam,
nordihydroguaiaretic acid (NDGA), GS-164, borneol esters, Synstab A,
Tubercidin and FR182877 (WS9885B). Furthermore, the invention provides a
method for the treatment of lesions of CNS axons the method comprising
the step of administering to a patient in the need thereof a
pharmaceutical composition comprising (i) one or more microtubule
stabilizing compounds selected from the group consisting of taxanes,
epothilones, laulimalides, sesquiterpene lactones, sarcodictyins,
diterpenoids, peloruside A, discodermolide, dicoumarol, ferulenol,
NSC12983, taccalonolide A, taccalonolide E, Rhazinilam,
nordihydroguaiaretic acid (NDGA), GS-164, borneol esters, Synstab A,
Tubercidin and FR182877 (WS9885B) and, optionally, (ii) further
comprising suitable formulations of carrier, stabilizers and/or
excipients, wherein the pharmaceutical composition is administered
locally directly into the lesion or immediately adjacent thereto.
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Publication type
Other: Patent
Publication date
2005-03-09
Application number
EP1700596A1
Application country
EP
Non-patent literature
Publications
Institute(s)
Institute for Tissue Engineering and Regenerative Medicine (ITERM)