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Sheng, M.* ; Ertürk, A.

Long-term depression: A cell biological view.

Philos. Trans. R. Soc. B - Biol. Sci. 369:20130138 (2014)
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Recent studies of the molecular mechanisms of long-term depression (LTD) suggest a crucial role for the signalling pathways of apoptosis (programmed cell death) in the weakening and elimination of synapses and dendritic spines. With this backdrop, we suggest that LTD can be considered as the electrophysiological aspect of a larger cell biological programme of synapse involution, which uses localized apoptotic mechanisms to sculpt synapses and circuits without causing cell death.
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Publication type Article: Journal article
Document type Review
Keywords Caspase ; Dendritic Spine ; Local Apoptosis ; Long-term Depression ; Long-term Potentiation ; Spine Elimination
Language english
Publication Year 2014
HGF-reported in Year 2014
ISSN (print) / ISBN 0962-8436
e-ISSN 1471-2970
Journal Philosophical Transactions of the Royal Society of London. Series B
Quellenangaben Volume: 369, Issue: 1633, Pages: , Article Number: 20130138 Supplement: ,
Publisher Royal Society of London
Reviewing status Peer reviewed
Institute(s) Institute for Tissue Engineering and Regenerative Medicine (ITERM)
DOI 10.1098/rstb.2013.0138
PubMed ID 24298141
Erfassungsdatum 2019-12-09
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