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Open Access Green as soon as Postprint is submitted to ZB.
Long-term depression: A cell biological view.
Philos. Trans. R. Soc. B - Biol. Sci. 369:20130138 (2014)
Recent studies of the molecular mechanisms of long-term depression (LTD) suggest a crucial role for the signalling pathways of apoptosis (programmed cell death) in the weakening and elimination of synapses and dendritic spines. With this backdrop, we suggest that LTD can be considered as the electrophysiological aspect of a larger cell biological programme of synapse involution, which uses localized apoptotic mechanisms to sculpt synapses and circuits without causing cell death.
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Publication type
Article: Journal article
Document type
Review
Keywords
Caspase ; Dendritic Spine ; Local Apoptosis ; Long-term Depression ; Long-term Potentiation ; Spine Elimination
ISSN (print) / ISBN
0962-8436
e-ISSN
1471-2970
Quellenangaben
Volume: 369,
Issue: 1633,
Article Number: 20130138
Publisher
Royal Society of London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Tissue Engineering and Regenerative Medicine (ITERM)