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Danielsen, P.H.* ; Knudsen, K.B.* ; Štrancar, J.* ; Umek, P.* ; Koklič, T.* ; Garvas, M.* ; Vanhala, E.* ; Savukoski, S.* ; Ding, Y. ; Madsen, A.M.* ; Jacobsen, N.R.* ; Weydahl, I.K.* ; Berthing, T.* ; Poulsen, S.S.* ; Schmid, O. ; Wolff, H.* ; Vogel, U.*

Effects of physicochemical properties of TiO2 nanomaterials for pulmonary inflammation, acute phase response and alveolar proteinosis in intratracheally exposed mice.

Toxicol. Appl. Pharmacol. 386:114830 (2020)
Publ. Version/Full Text Research data DOI PMC
Open Access Hybrid
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Nanomaterial (NM) characteristics may affect the pulmonary toxicity and inflammatory response, including specific surface area, size, shape, crystal phase or other surface characteristics. Grouping of TiO2 in hazard assessment might be challenging because of variation in physicochemical properties. We exposed C57BL/6 J mice to a single dose of four anatase TiO2 NMs with various sizes and shapes by intratracheal instillation and assessed the pulmonary toxicity 1, 3, 28, 90 or 180 days post-exposure. The quartz DQ12 was included as benchmark particle. Pulmonary responses were evaluated by histopathology, electron microscopy, bronchoalveolar lavage (BAL) fluid cell composition and acute phase response. Genotoxicity was evaluated by DNA strand break levels in BAL cells, lung and liver in the comet assay. Multiple regression analyses were applied to identify specific TiO2 NMs properties important for the pulmonary inflammation and acute phase response. The TiO2 NMs induced similar inflammatory responses when surface area was used as dose metrics, although inflammatory and acute phase response was greatest and more persistent for the TiO2 tube. Similar histopathological changes were observed for the TiO2 tube and DQ12 including pulmonary alveolar proteinosis indicating profound effects related to the tube shape. Comparison with previously published data on rutile TiO2 NMs indicated that rutile TiO2 NMs were more inflammogenic in terms of neutrophil influx than anatase TiO2 NMs when normalized to total deposited surface area. Overall, the results suggest that specific surface area, crystal phase and shape of TiO2 NMs are important predictors for the observed pulmonary effects of TiO2 NMs.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Titanium Dioxide ; Nanoparticles ; Crystal Phase ; Inflammation ; Acute Phase Response ; Pulmonary Alveolar Proteinosis; Dna Strand Breaks; Carbon Nanotubes; Inhalation; Lung; Nanoparticles; Cytotoxicity; Instillation; Particles; Cells; Genotoxicity
Language
Publication Year 2020
Prepublished in Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 0041-008X
e-ISSN 1096-0333
Journal Toxicology and Applied Pharmacology
Quellenangaben Volume: 386, Issue: , Pages: , Article Number: 114830 Supplement: ,
Publisher Elsevier
Publishing Place 525 B St, Ste 1900, San Diego, Ca 92101-4495 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-505000-008
DOI 10.1016/j.taap.2019.114830
WOS ID WOS:000508286500007
Scopus ID 85076036471
PubMed ID 31734322
Erfassungsdatum 2020-01-15
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