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Open Access Green as soon as Postprint is submitted to ZB.
IL-17 and IL-22: Siblings, not twins.
Trends Immunol. 31, 354-361 (2010)
T helper (Th) cell subsets secrete cytokines that regulate other immune cells. Interleukin (IL)-17 and IL-22 belong to a new class of cytokines with predominant effects on epithelial cells. Thus, these cytokines are key molecules in several disease processes. IL-17 and IL-22 are released by leukocytes such as Th and natural killer cell populations. Both IL-17 and IL-22 induce an innate immune response in epithelial cells, but their functional spectra are generally distinct. IL-17 induces an inflammatory tissue response and is involved in the pathogenesis of several autoimmune diseases, whereas IL-22 is protective/regenerative. This review juxtaposes IL-17 and IL-22 and describes overlaps and differences regarding their cellular sources, biochemical structure, signaling cascades in target cells, and function.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
t-helper-cells; collagen-induced arthritis; growth-factor-beta; messenger-rna stabilization; inflammatory-bowel-disease; aryl-hydrocarbon receptor; mucosal host-defense; human t(h)17 cells; human th17 cells; ror-gamma-t
ISSN (print) / ISBN
1471-4906
e-ISSN
1471-4981
Journal
Trends in Immunology
Quellenangaben
Volume: 31,
Issue: 9,
Pages: 354-361
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)
Institute of Epidemiology (EPI)
Institute of Epidemiology (EPI)