PuSH - Publication Server of Helmholtz Zentrum München: Metabolic impact of pheochromocytoma/ paraganglioma: Targeted metabolomics in patients before and after tumor removal.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Erlic, Z.* ; Kurlbaum, M.* ; Deutschbein, T.* ; Noelting, S.* ; Prejbisz, A.* ; Timmers, H.J.* ; Richter, S.* ; Prehn, C. ; Weismann, D.* ; Adamski, J. ; Januszewicz, A.* ; Reincke, M.* ; Fassnacht, M.* ; Robledo, M.* ; Eisenhofer, G.* ; Beuschlein, F.* ; Kroiss, M.*

Metabolic impact of pheochromocytoma/ paraganglioma: Targeted metabolomics in patients before and after tumor removal.

Eur. J. Endocrinol. 181, 647-657 (2019)

Publ. Version/Full Text

DOI

PMC

	Free by publisher

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

Objective: Excess catecholamine release by pheochromocytomas and paragang liomas (PPGL) leads to characteristic clinical features and increased morbidity and mortality. The in fluence of PPGLs on metabolism is ill described but may impact diagnosis and management. The objective of this study wa s to systematically and quantitatively study PPGL-induced metabolic changes at a systems level. Design: Targeted metabolomics by liquid chromatography-tandem mass spe ctrometry of plasma specimens in a clinically well-characterized prospective cohort study. Methods: Analyses of metabolic profiles of plasma specimens from 56 pros pectively enrolled and clinically well-characterized patients (23 males, 33 females) with catecholamin e-producing PPGL before and after surgery, as well as measurement of 24-h urinary catecholamine using LC-MS/MS. Results: From 127 analyzed metabolites, 15 were identified with significa nt changes before and after surgery: Five amino acids/biogenic amines (creatinine, histidine, ornithine, sarcosine, tyrosine) and one glycerophospholipid (PCaeC34:2) with increased concentrations and six glycerophospholipids (PCaaC38:1, PCaaC42:0, PCaeC40:2, PCaeC42:5, PCaeC44:5, PCaeC44:6), two sphingomyelins (SMC24:1, SMC26:1) and hexose with decreased levels after surgery. Patients with a noradrenergic tumor phenotype had more pronounced alterations compared to those with an adrenergic tumor phenotype. Weak, but significant correlation s for 8 of these 15 metabolites with total urine catecholamine levels were identified. Conclusions: This first large prospective metabolomics analysis of PPGL pati ents demonstrates broad metabolic consequences of catecholamine excess. Robust impact on lipid an d amino acid metabolism may contribute to increased morbidity of PPGL patients.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Oxidative Stress; Inflammation; Histidine; Endocrine; Diagnosis; Markers

ISSN (print) / ISBN 0804-4643

e-ISSN 1479-683X

Journal European Journal of Endocrinology

Quellenangaben Volume: 181, Issue: 6, Pages: 647-657

Publisher BioScientifica

Publishing Place Starling House, 1600 Bristol Parkway N, Bristol, England

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Molekulare Endokrinologie und Metabolismus (MEM)