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Maternal weight, weight gain and metabolism are associated with changes in fetal heart rate and variabilit.
Obesity 28, 114-121 (2020)
Objective: Prepregnancy obesity and extensive weight gain can lead to diseases in the offspring later in life. The aim of this study was to evaluate the effect of anthropometric and metabolic factors on the fetal autonomic nervous system (ANS) in uncomplicated pregnancies. Methods: A total of 184 pregnant women in the second or third trimester were included, and for 104 women, maternal insulin sensitivity (ISI) was determined. Fetal heart rate (HR) and heart rate variability (HRV) were determined by magnetic recording. Associations of maternal prepregnancy BMI, weight gain, and ISI with fetal HR and HRV were evaluated by ANCOVA, partial correlation, and mediation analysis. Results: HR was increased and HRV decreased in fetuses of mothers with overweight or obesity in comparison to normal-weight mothers. Fetal HR was negatively correlated with maternal weight gain. Maternal prepregnancy BMI was positively correlated with fetal high frequency and was negatively correlated with low frequency and low/high frequency ratio. Maternal ISI showed a negative correlation with fetal HR. Conclusions: The results show that the fetal ANS is sensitive to alterations of prepregnancy BMI, weight changes, and glucose metabolism. These findings highlight the importance of the intrauterine environment on the developing ANS and the possible programming of obesity.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
1930-7381
e-ISSN
1930-739X
Journal
Obesity
Quellenangaben
Volume: 28,
Issue: 1,
Pages: 114-121
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed