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Pfaar, O.* ; Agache, I.* ; de Blay, F.* ; Bonini, S.* ; Chaker, A.M.* ; Durham, S.R.* ; Gawlik, R.* ; Hellings, P.W.* ; Jutel, M.* ; Kleine-Tebbe, J.* ; Klimek, L.* ; Kopp, M.V.* ; Nandy, A.* ; Rabin, R.L.* ; van Ree, R.* ; Renz, H.* ; Roberts, G.* ; Salapatek, A.M.* ; Schmidt-Weber, C.B. ; Shamji, M.H.* ; Sturm, G.J.* ; Virchow, J.C.* ; Wahn, U.* ; Willers, C.* ; Zieglmayer, P.* ; Akdis, C.A.*

Perspectives in allergen immunotherapy: 2019 and beyond.

Allergy 74, 3-25 (2019)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
The seventh "Future of the Allergists and Specific Immunotherapy (FASIT)" workshop held in 2019 provided a platform for global experts from academia, allergy clinics, regulatory authorities and industry to review current developments in the field of allergen immunotherapy (AIT). Key domains of the meeting included the following: (a) Biomarkers for AIT and allergic asthma; (b) visions for the future of AIT; (c) progress and data for AIT in asthma and the updates of GINA and EAACI Asthma Guidelines (separated for house dust mite SCIT, SLIT tablets and SLIT drops; patient populations) including a review of clinically relevant endpoints in AIT studies in asthma; (d) regulatory prerequisites such as the "Therapy Allergen Ordinance" in Germany; (e) optimization of trial design in AIT clinical research; (f) challenges planning and conducting phase III (field) studies and the future role of Allergen Exposure Chambers (AEC) in AIT product development from the regulatory point of view. We report a summary of panel discussions of all six domains and highlight unmet needs and possible solutions for the future.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Allergen Exposure Chamber ; Allergen Immunotherapy ; Allergic Asthma ; Biomarker ; Clinical Trials; Grass-pollen Immunotherapy; Eaaci Ait Guidelines; Sublingual Immunotherapy; Double-blind; Subcutaneous Immunotherapy; Clinical-efficacy; Treatment Phase; Venom Allergy; Food Allergy; Asthma
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Quellenangaben Volume: 74, Issue: S108, Pages: 3-25 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute for Allergy Research (IAF)