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Pfaar, O.* ; Agache, I.* ; de Blay, F.* ; Bonini, S.* ; Chaker, A.M.* ; Durham, S.R.* ; Gawlik, R.* ; Hellings, P.W.* ; Jutel, M.* ; Kleine-Tebbe, J.* ; Klimek, L.* ; Kopp, M.V.* ; Nandy, A.* ; Rabin, R.L.* ; van Ree, R.* ; Renz, H.* ; Roberts, G.* ; Salapatek, A.M.* ; Schmidt-Weber, C.B. ; Shamji, M.H.* ; Sturm, G.J.* ; Virchow, J.C.* ; Wahn, U.* ; Willers, C.* ; Zieglmayer, P.* ; Akdis, C.A.*

Perspectives in allergen immunotherapy: 2019 and beyond.

Allergy 74, 3-25 (2019)
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The seventh "Future of the Allergists and Specific Immunotherapy (FASIT)" workshop held in 2019 provided a platform for global experts from academia, allergy clinics, regulatory authorities and industry to review current developments in the field of allergen immunotherapy (AIT). Key domains of the meeting included the following: (a) Biomarkers for AIT and allergic asthma; (b) visions for the future of AIT; (c) progress and data for AIT in asthma and the updates of GINA and EAACI Asthma Guidelines (separated for house dust mite SCIT, SLIT tablets and SLIT drops; patient populations) including a review of clinically relevant endpoints in AIT studies in asthma; (d) regulatory prerequisites such as the "Therapy Allergen Ordinance" in Germany; (e) optimization of trial design in AIT clinical research; (f) challenges planning and conducting phase III (field) studies and the future role of Allergen Exposure Chambers (AEC) in AIT product development from the regulatory point of view. We report a summary of panel discussions of all six domains and highlight unmet needs and possible solutions for the future.
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Publication type Article: Journal article
Document type Review
Keywords Allergen Exposure Chamber ; Allergen Immunotherapy ; Allergic Asthma ; Biomarker ; Clinical Trials; Grass-pollen Immunotherapy; Eaaci Ait Guidelines; Sublingual Immunotherapy; Double-blind; Subcutaneous Immunotherapy; Clinical-efficacy; Treatment Phase; Venom Allergy; Food Allergy; Asthma
Language
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Quellenangaben Volume: 74, Issue: S108, Pages: 3-25 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed
Institute(s) Institute for Allergy Research (IAF)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Allergy
PSP Element(s) G-505400-001
DOI 10.1111/all.14077
WOS ID WOS:000505281100001
Scopus ID 85077081957
PubMed ID 31872476
Erfassungsdatum 2020-01-28
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