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Hofmann, W.* ; Li, W.B. ; Friedland, W. ; Miller, B.W.* ; Madas, B.* ; Bardies, M.* ; Balashazy, I.*

Internal microdosimetry of alpha-emitting radionuclides.

Radiat. Environ. Biophys. 59, 29–62 (2020)
Postprint DOI PMC
Open Access Green
At the tissue level, energy deposition in cells is determined by the microdistribution of alpha-emitting radionuclides in relation to sensitive target cells. Furthermore, the highly localized energy deposition of alpha particle tracks and the limited range of alpha particles in tissue produce a highly inhomogeneous energy deposition in traversed cell nuclei. Thus, energy deposition in cell nuclei in a given tissue is characterized by the probability of alpha particle hits and, in the case of a hit, by the energy deposited there. In classical microdosimetry, the randomness of energy deposition in cellular sites is described by a stochastic quantity, the specific energy, which approximates the macroscopic dose for a sufficiently large number of energy deposition events. Typical examples of the alpha-emitting radionuclides in internal microdosimetry are radon progeny and plutonium in the lungs, plutonium and americium in bones, and radium in targeted radionuclide therapy. Several microdosimetric approaches have been proposed to relate specific energy distributions to radiobiological effects, such as hit-related concepts, LET and track length-based models, effect-specific interpretations of specific energy distributions, such as the dual radiation action theory or the hit-size effectiveness function, and finally track structure models. Since microdosimetry characterizes only the initial step of energy deposition, microdosimetric concepts are most successful in exposure situations where biological effects are dominated by energy deposition, but not by subsequently operating biological mechanisms. Indeed, the simulation of the combined action of physical and biological factors may eventually require the application of track structure models at the nanometer scale.
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Publication type Article: Journal article
Document type Review
Keywords Internal Dosimetry ; Microdosimetry ; Alpha-emitting Radionuclides; Radon Decay Products; Lung-cancer Risk; Monte-carlo-simulation; Particle Digital Autoradiography; Extranuclear Cell Sensitivity; Cultured-mammalian-cells; Small-scale Dosimetry; Double-strand Breaks; Short Dna Fragments; Track-length Model
Language english
Publication Year 2020
Prepublished in Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 0301-634X
e-ISSN 1432-2099
Journal Radiation and Environmental Biophysics
Quellenangaben Volume: 59, Issue: , Pages: 29–62 Article Number: , Supplement: ,
Publisher Springer
Publishing Place 233 Spring St, New York, Ny 10013 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Medicine (IRM)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Radiation Sciences
PSP Element(s) G-501391-001
DOI 10.1007/s00411-019-00826-w
WOS ID WOS:000503661300001
PubMed ID 31863162
Erfassungsdatum 2020-01-13
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