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Barbosa-Yañez, R.L.* ; Markova, M.* ; Dambeck, U.* ; Honsek, C.* ; Machann, J. ; Schüler, R.* ; Kabisch, S.* ; Pfeiffer, A.F.H.*

Predictive effect of GIPR SNP rs10423928 on glucose metabolism liver fat and adiposity in prediabetic and diabetic subjects.

Peptides 125:170237 (2020)

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	Open Access Green

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The gastric inhibitory polypeptide receptor (GIPR) regulates postprandial metabolism. In this context GIPR SNP rs10423928 seems toplay an important role in modulating glucose metabolism and insulinsensitivity. However, evidence regarding thisparticular SNP is still vague.In this study, we collected baseline data from four different dietaryintervention studies. We genotyped 424 subjects with prediabetes and 73with diabetes for GIPR SNP rs10423928 and examined its impact on glucosemetabolism, insulin sensitivity and body fat accumulation.We extended previous data by showing that carriers of the A allele withprediabetes displayed increased fasting glucose (p = 0.015). Unexpectedly,A allele carriers showed lower glucose levels 2 h (p = 0.021) after anoral glucose challenge compared to T/T homozygous individuals. A allelecarriers also showed significantly higher insulin sensitivity (p < 0.001)(assessed by Cederholm Index), indicating an enhanced beta-cell response.This study points to a potential protective role for rs10423928 inglucose metabolism and insulin sensitivity in subjects with prediabetes.Further studies are necessary to confirm these results.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Glucose-dependent Insulinotropic Peptide ; Gipr ; Glucose Metabolism ; Insulin Sensitivity ; Prediabetes ; Diabetes; Dependent Insulinotropic Polypeptide; Physiological Characterization; Receptor; Tissue; Expression; Resistance; Cloning; Inhibition; Responses; Release

ISSN (print) / ISBN 0196-9781

e-ISSN 1873-5169

Journal Peptides

Quellenangaben Volume: 125, Article Number: 170237

Publisher Elsevier

Publishing Place New York, NY

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)