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Jetzfellner, T. ; Razansky, D. ; Rosenthal, A.* ; Schulz, R.B.* ; Englmeier, K.-H. ; Ntziachristos, V.

Iterative finite-element-based inversion for quantified detection of molecular targets using optoacoustic tomography.

Proc. SPIE 7258, (Suppl.1)  :725812 (2009)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
We describe an improved optoacoustic tomography method, that utilizes a diffusion-based photon propagation model in order to obtain quantified reconstruction of targets embedded deep in heterogeneous scattering and absorbing tissue. For the correction we utilize an iterative finite-element solution of the light diffusion equation to build a photon propagation model. We demonstrate image improvements achieved by this method by using tissue-mimicking phantom measurements. The particular strength of the method is its ability to achieve quantified reconstructions in non-uniform illumination configurations resembling whole-body small animal imaging scenarios.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Finite Element Methods ; Iterative Methods ; Normalization Methods ; Optoacoustics ; Tomographic Imaging
Language english
Publication Year 2009
HGF-reported in Year 2009
ISSN (print) / ISBN 0277-786X
e-ISSN 1996-756X
Quellenangaben Volume: 7258, Issue: , Pages: , Article Number: 725812, Supplement: (Suppl.1)  
Series Proceedings of SPIE
Publisher SPIE
Publishing Place Bellingham, WA
Reviewing status Peer reviewed
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-003
G-505500-001
Scopus ID 66749190977
Erfassungsdatum 2009-09-11