Iterative finite-element-based inversion for quantified detection of molecular targets using optoacoustic tomography.
    
    
        
    
    
        
        Proc. SPIE 7258, (Suppl.1)  :725812 (2009)
    
    
 	
    
	
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	    We describe an improved optoacoustic tomography method, that utilizes a diffusion-based photon propagation model in order to obtain quantified reconstruction of targets embedded deep in heterogeneous scattering and absorbing tissue. For the correction we utilize an iterative finite-element solution of the light diffusion equation to build a photon propagation model. We demonstrate image improvements achieved by this method by using tissue-mimicking phantom measurements. The particular strength of the method is its ability to achieve quantified reconstructions in non-uniform illumination configurations resembling whole-body small animal imaging scenarios.
	
	
	    
	
       
      
	
	    
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        Publication type
        Article: Journal article
    
 
    
        Document type
        Scientific Article
    
 
    
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        Keywords
        Finite Element Methods ; Iterative Methods ; Normalization Methods ; Optoacoustics ; Tomographic Imaging
    
 
    
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        Language
        english
    
 
    
        Publication Year
        2009
    
 
    
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        HGF-reported in Year
        2009
    
 
    
    
        ISSN (print) / ISBN
        0277-786X
    
 
    
        e-ISSN
        1996-756X
    
 
    
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	    Volume: 7258,  
	    Issue: ,  
	    Pages: ,  
	    Article Number: 725812,  
	    Supplement: (Suppl.1)   
	
    
 
    
        
            Series
            Proceedings of SPIE
        
 
        
            Publisher
            SPIE
        
 
        
            Publishing Place
            Bellingham, WA
        
 
	
        
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        Reviewing status
        Peer reviewed
    
 
     
    
        POF-Topic(s)
        30205 - Bioengineering and Digital Health
    
 
    
        Research field(s)
        Enabling and Novel Technologies
    
 
    
        PSP Element(s)
        G-505500-003
G-505500-001
    
 
    
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        Erfassungsdatum
        2009-09-11