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Lohöfer, F.* ; Buchholz, R.* ; Glinzer, A.* ; Huber, K. ; Haas, H.* ; Kaissis, G.* ; Feuchtinger, A. ; Aichler, M. ; Sporns, P.B.* ; Höltke, C.* ; Stölting, M.* ; Schilling, F.* ; Botnar, R.M.* ; Kimm, M.A.* ; Faber, C.* ; Walch, A.K. ; Zernecke, A.* ; Karst, U.* ; Wildgruber, M.*

Mass Spectrometry imaging of atherosclerosis-affine Gadofluorine following Magnetic Resonance imaging.

Sci. Rep. 10:79 (2020)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Molecular imaging of atherosclerosis by Magnetic Resonance Imaging (MRI) has been impaired by a lack of validation of the specific substrate responsible for the molecular imaging signal. We therefore aimed to investigate the additive value of mass spectrometry imaging (MSI) of atherosclerosis-affine Gadofluorine P for molecular MRI of atherosclerotic plaques. Atherosclerotic Ldlr(-/-) mice were investigated by high-field MRI (7T) at different time points following injection of atherosclerosis-affine Gadofluorine P as well as at different stages of atherosclerosis formation (4, 8, 16 and 20 weeks of HFD). At each imaging time point mice were immediately sacrificed after imaging and aortas were excised for mass spectrometry imaging: Matrix Assisted Laser Desorption Ionization (MALDI) Imaging and Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS) imaging. Mass spectrometry imaging allowed to visualize the localization and measure the concentration of the MR imaging probe Gadofluorine P in plaque tissue ex vivo with high spatial resolution and thus adds novel and more target specific information to molecular MR imaging of atherosclerosis.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Plaque; Tissue; Quantification; Model; Ms
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Journal Scientific Reports
Quellenangaben Volume: 10, Issue: 1, Pages: , Article Number: 79 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Research Unit Analytical Pathology (AAP)
CF Pathology & Tissue Analytics (CF-PTA)
POF-Topic(s) 30205 - Bioengineering and Digital Health
30505 - New Technologies for Biomedical Discoveries
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-500390-001
A-630600-001
Grants British Heart Foundation
DOI 10.1038/s41598-019-57075-6
WOS ID WOS:000517989900030
Scopus ID 85077712010
PubMed ID 31919465
Erfassungsdatum 2020-03-17
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