PuSH - Publication Server of Helmholtz Zentrum München

Zengini, E.* ; Hatzikotoulas, K.* ; Tachmazidou, I.* ; Steinberg, J.* ; Hartwig, F.P.* ; Southam, L.* ; Hackinger, S.* ; Boer, C.G.* ; Styrkarsdottir, U.* ; Gilly, A.* ; Suveges, D.* ; Killian, B.* ; Ingvarsson, T.* ; Jonsson, H.* ; Babis, G.C.* ; McCaskie, A.W.* ; Uitterlinden, A.G.* ; van Meurs, J.B.J.* ; Thorsteinsdottir, U.* ; Stefansson, K.* ; Davey Smith, G.* ; Wilkinson, J.M.* ; Zeggini, E.

Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.

Nat. Genet. 50, 549-558 (2018)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Osteoarthritis is a common complex disease imposing a large public-health burden. Here, we performed a genome-wide association study for osteoarthritis, using data across 16.5 million variants from the UK Biobank resource. After performing replication and meta-analysis in up to 30,727 cases and 297,191 controls, we identified nine new osteoarthritis loci, in all of which the most likely causal variant was noncoding. For three loci, we detected association with biologically relevant radiographic endophenotypes, and in five signals we identified genes that were differentially expressed in degraded compared with intact articular cartilage from patients with osteoarthritis. We established causal effects on osteoarthritis for higher body mass index but not for triglyceride levels or genetic predisposition to type 2 diabetes.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 50, Issue: 4, Pages: 549-558 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Translational Genomics (ITG)