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Georgi, A.* ; Jamra, R.A.* ; Schumacher, J.* ; Becker, T.* ; Schmael, C.* ; Deschner, M.* ; Höfels, S.* ; Wulff, M.* ; Schwarz, M.* ; Klopp, N. ; Illig, T. ; Propping, P.* ; Cichon, S.* ; Nöthen, M.M.* ; Rietschel, M.* ; Schulze, T.G.*

No association between genetic variants at the GRIN1 gene and bipolar disorder in a Germany sample.

Psychiatr. Genet. 16, 183-184 (2006)
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Disturbed glutamatergic neurotransmission has been implicated in the pathogenesis of schizophrenia and bipolar disorder, with the N-methy-D-aspartate receptors being in the focus of research. The NR1 subunit, which is encoded by the gene GRIN1, plays a key role in the functionality of N-methy-D-aspartate receptors. We tested the association between GRIN1 and bipolar disorder in a sample of German descent, consisting of 306 bipolar disorder patients and 319 population-based controls. No significant association was found. In accordance with our recent findings, we hypothesized that restricting case definition to individuals with a history of persecutory delusions might clarify the relationship between bipolar disorder and GRIN1. This stratified analysis did not yield any significant association either. Our results do not support an association of the GRIN1 gene with bipolar disorder in the German population. © 2006 Lippincott Williams & Wilkins.
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Publication type Article: Journal article
Document type Scientific Article
Keywords bipolar disorder; glutamateric; neurotransmission; GRIN1
Language english
Publication Year 2006
HGF-reported in Year 2006
ISSN (print) / ISBN 0955-8829
e-ISSN 1473-5873
Journal Psychiatric Genetics
Quellenangaben Volume: 16, Issue: 5, Pages: 183-184 Article Number: , Supplement: ,
Publisher Lippincott Williams & Wilkins
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503900-003
DOI 10.1097/01.ypg.0000242194.36150.2b
Scopus ID 33748754260
Erfassungsdatum 2006-12-31
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