Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
Publ. Version/Full Text
DOI
PMC
 |
Open Access Gold (Paid Option) |
|
as soon as is submitted to ZB.
Regeneration of the central nervous system-principles from brain regeneration in adult zebrafish.
World J. Stem Cells 12, 8-24 (2020)
Poor recovery of neuronal functions is one of the most common healthcare challenges for patients with different types of brain injuries and/or neurodegenerative diseases. Therapeutic interventions face two major challenges: (1) How to generate neurons de novo to replenish the neuronal loss caused by injuries or neurodegeneration (restorative neurogenesis) and (2) How to prevent or limit the secondary tissue damage caused by long-term accumulation of glial cells, including microglia, at injury site (glial scar). In contrast to mammals, zebrafish have extensive regenerative capacity in numerous vital organs, including the brain, thus making them a valuable model to improve the existing therapeutic approaches for human brain repair. In response to injuries to the central nervous system (CNS), zebrafish have developed specific mechanisms to promote the recovery of the lost tissue architecture and functionality of the damaged CNS. These mechanisms include the activation of a restorative neurogenic program in a specific set of glial cells (ependymoglia) and the resolution of both the glial scar and inflammation, thus enabling proper neuronal specification and survival. In this review, we discuss the cellular and molecular mechanisms underlying the regenerative ability in the adult zebrafish brain and conclude with the potential applicability of these mechanisms in repair of the mammalian CNS.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Review
Keywords
Zebrafish ; Central Nervous System ; Brain Injury ; Glial Scar ; Regeneration ; Restorative Neurogenesis ; Neural Stem Cells ; Inflammation; Neural Stem-cells; Live Imaging Reveals; Radial Glia; Neuronal Regeneration; Progenitor Cells; In-vivo; Stab Injury; Neurogenesis; Microglia; Inflammation
ISSN (print) / ISBN
1948-0210
e-ISSN
1948-0210
Journal
World journal of stem cells
Quellenangaben
Volume: 12,
Issue: 1,
Pages: 8-24
Publisher
Beijing Baishideng BioMed Scientific Co.
Publishing Place
Beijing, China
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)