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Estrada, H.* ; Rebling, J.* ; Sivert, W.* ; Hladik, D. ; Hofmann, U.* ; Gottschalk, S.* ; Tapio, S. ; Multhoff, G.* ; Razansky, D.

Intravital optoacoustic and ultrasound bio-microscopy reveal radiation-inhibited skull angiogenesis.

Bone 133:115251 (2020)
Postprint DOI PMC
Open Access Green
Angiogenesis is critical in bone development and growth. Dense, large-scale, and multi-layered vascular networks formed by thin-walled sinusoidal vessels perfuse the plate bones and play an important role in bone repair. Yet, the intricate functional morphology of skull microvasculature remains poorly understood as it is difficult to visualize using existing intravital microscopy techniques. Here we introduced an intravital, fully-transcranial imaging approach based on hybrid optoacoustic and ultrasound bio-microscopy for large-scale observations and quantitative analysis of the vascular morphology, angiogenesis, vessel remodeling, and subsurface roughness in murine skulls. Our approach revealed radiation-inhibited angiogenesis in the skull bone. We also observed previously undocumented sinusoidal vascular networks spanning the entire skullcap, thus opening new vistas for studying the complex interactions between calvarial, pial, and cortical vascular systems.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Skull Vasculature ; Radiation ; Optoacoustic Microscopy ; Ultrasound Microscopy ; Bone Angiogenesis ; Image Segmentation ; Quantitative Vasculature Analysis; Bone-marrow; Ionizing-radiation; Cells; Mechanisms; Brain; Veins
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 8756-3282
e-ISSN 1873-2763
Journal Bone: Official Journal of the International Bone and Mineral Society
Quellenangaben Volume: 133, Issue: , Pages: , Article Number: 115251 Supplement: ,
Publisher Elsevier
Publishing Place Ste 800, 230 Park Ave, New York, Ny 10169 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Institute of Radiation Biology (ISB)
POF-Topic(s) 30205 - Bioengineering and Digital Health
30202 - Environmental Health
Research field(s) Enabling and Novel Technologies
Radiation Sciences
PSP Element(s) G-505590-001
G-500200-001
DOI 10.1016/j.bone.2020.115251
WOS ID WOS:000517355400022
Scopus ID 85079092760
PubMed ID 31978616
Erfassungsdatum 2020-03-18
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