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Ehrmann, S.* ; Schmid, O. ; Darquenne, C.* ; Rothen-Rutishauser, B.* ; Sznitman, J.* ; Yang, L. ; Barosova, H.* ; Vecellio, L.* ; Mitchell, J.* ; Henze-Vourc´h, N.*

Innovative preclinical models for pulmonary drug delivery research.

Expert Opin. Drug Deliv. 17, 463-478 (2020)
Postprint DOI PMC
Open Access Green
Introduction: Pulmonary drug delivery is a complex field of research combining physics which drive aerosol transport and deposition and biology which underpins efficacy and toxicity of inhaled drugs. A myriad of preclinical methods, ranging from in-silico to in-vitro, ex-vivo and in-vivo, can be implemented.Areas covered: The present review covers in-silico mathematical and computational fluid dynamics modelization of aerosol deposition, cascade impactor technology to estimated drug delivery and deposition, advanced in-vitro cell culture methods and associated aerosol exposure, lung-on-chip technology, ex-vivo modeling, in-vivo inhaled drug delivery, lung imaging, and longitudinal pharmacokinetic analysis.Expert opinion: No single preclinical model can be advocated; all methods are fundamentally complementary and should be implemented based on benefits and drawbacks to answer specific scientific questions. The overall best scientific strategy depends, among others, on the product under investigations, inhalation device design, disease of interest, clinical patient population, previous knowledge. Preclinical testing is not to be separated from clinical evaluation, as small proof-of-concept clinical studies or conversely large-scale clinical big data may inform preclinical testing. The extend of expertise required for such translational research is unlikely to be found in one single laboratory calling for the setup of multinational large-scale research consortiums.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Aerosolization ; Animal Models ; Cell Culture Techniques ; Inhalation ; Nebulization ; Theoretical Modeling; Alveolar Epithelial-cells; Aerosol Inhalation Inoculation; In-vitro; Respiratory-tract; Traditional Intranasal; Particle Deposition; Monoclonal-antibody; Culture Models; Lung; Vivo
ISSN (print) / ISBN 1742-5247
e-ISSN 1744-7593
Journal Expert Opinion on Drug Delivery
Quellenangaben Volume: 17, Issue: 4, Pages: 463-478 Article Number: , Supplement: ,
Publisher Informa Healthcare
Publishing Place 2-4 Park Square, Milton Park, Abingdon Or14 4rn, Oxon, England
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)