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Bartelt, A. ; Widenmaier, S.B.*

Proteostasis in thermogenesis and obesity.

Biol. Chem. 401, 1019-1030 (2020)
Postprint DOI PMC
The proper production, degradation, folding and activity of proteins, proteostasis, is essential for any cellular function. From single cell organisms to humans, selective pressures have led to the evolution of adaptive programs that ensure proteins are properly produced and disposed of when necessary. Environmental factors such as temperature, nutrient availability, pathogens as well as predators have greatly influenced the development of mechanisms such as the unfolded protein response, endoplasmic reticulum-associated protein degradation and autophagy, working together in concert to secure cellular proteostasis. In our modern society, the metabolic systems of the human body face the distinct challenge of changed diets, chronic overnutrition and sedentary lifestyles. Obesity and excess white adipose tissue accumulation are linked to a cluster of metabolic diseases and disturbed proteostasis is a common feature. Conversely, processes that promote energy expenditure such as exercise, shivering as well as non-shivering thermogenesis by brown adipose tissue (BAT) and beige adipocytes counter-act metabolic dysfunction. Here we review the basic concepts of proteostasis in obesity-linked metabolic diseases and focus on adipocytes, which are critical regulators of mammalian energy metabolism.
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Publication type Article: Journal article
Document type Review
Keywords Adipocyte ; Endoplasmic Reticulum ; Obesity ; Proteostasis ; Thermogenesis; Brown Adipose-tissue; Endoplasmic-reticulum Stress; Unfolded Protein Response; Transcription Factor; Er Stress; Proteasomal Degradation; Insulin-resistance; Links Obesity; Mechanisms; Adipocytes
ISSN (print) / ISBN 1431-6730
e-ISSN 1437-4315
Journal Biological Chemistry
Quellenangaben Volume: 401, Issue: 9, Pages: 1019-1030 Article Number: , Supplement: ,
Publisher de Gruyter
Publishing Place Genthiner Strasse 13, D-10785 Berlin, Germany
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)