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Cortijo, S.* ; Wardenaar, R.* ; Colomé-Tatché, M. ; Gilly, A.* ; Etcheverry, M.* ; Labadie, K.* ; Caillieux, E.* ; Hospital, F.* ; Aury, J.M.* ; Wincker, P.* ; Roudier, F.* ; Jansen, R.C.* ; Colot, V.* ; Johannes, F.*

Mapping the epigenetic basis of complex traits.

Science 343, 1145-1148 (2014)
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Quantifying the impact of heritable epigenetic variation on complex traits is an emerging challenge in population genetics. Here, we analyze a population of isogenic Arabidopsis lines that segregate experimentally induced DNA methylation changes at hundreds of regions across the genome. We demonstrate that several of these differentially methylated regions (DMRs) act as bona fide epigenetic quantitative trait loci (QTL(epi)), accounting for 60 to 90% of the heritability for two complex traits, flowering time and primary root length. These QTL(epi) are reproducible and can be subjected to artificial selection. Many of the experimentally induced DMRs are also variable in natural populations of this species and may thus provide an epigenetic basis for Darwinian evolution independently of DNA sequence changes.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2014
HGF-reported in Year 2014
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Journal Science
Quellenangaben Volume: 343, Issue: 6175, Pages: 1145-1148 Article Number: , Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-554200-001
DOI 10.1126/science.1248127
PubMed ID 24505129
Erfassungsdatum 2020-02-18
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