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Open Access Green as soon as Postprint is submitted to ZB.
Post-prandial decrease of circulating human ghrelin levels.
J. Endocrinol. Invest. 24, RC19-21 (2001)
Ghrelin, an endogenous ligand of the GH secretagogue-receptor, has recently been shown to stimulate GH secretion and to have orexigenic and adipogenic effects in rodents, but little is known about its regulation and biological function in humans. Gastric motor function is under control of the central nervous system; however, the afferent and efferent loops of this feedback control mechanism remain to be elucidated. In the study presented here we investigated the effect of nutrient intake on circulating human ghrelin levels, and a possible association between ghrelin levels and gastric emptying. Ten healthy volunteers received a standard meal after an overnight fast. Food intake significantly decreased plasma ghrelin levels from 248.5 +/- 15.0 to 179.5 +/- 17.9 fmol/ml (120 min after meal, p=0.047). Gastric emptying half-time (non-invasive 13C-octanoic acid breath test) was correlated with fasting plasma ghrelin levels (r=0.74, p=0.0013). Ghrelin appears to be one possible candidate to provide feedback signaling between nutrient intake, gastric motor function and the central nervous system.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2001
HGF-reported in Year
2001
ISSN (print) / ISBN
0391-4097
e-ISSN
1720-8386
Quellenangaben
Volume: 24,
Issue: 6,
Pages: RC19-21
Publisher
Springer
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)
PubMed ID
11434675
Erfassungsdatum
2020-02-20