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Open Access Green as soon as Postprint is submitted to ZB.
Genome-wide association studies on IgE regulation: Are genetics of IgE also genetics of atopic disease?
Curr. Opin. Allergy Clin. Immunol. 10, 408-417 (2010)
PURPOSE OF REVIEW: Total IgE levels are considered a useful endophenotype for studying the genetics of atopic diseases. However, the role and significance of genetic factors influencing IgE regulation for atopic diseases as endpoints is unclear.RECENT FINDINGS: Recently, genome-wide association studies (GWASs) have been applied to atopic traits with considerable success. A total of seven published GWASs on asthma, one GWAS on eczema, and one GWAS on total IgE have reported 11 new loci. Most of these loci appear to be trait-specific. A notable exception is the Th2 cytokine cluster, where genetic variation seems to be relevant across atopic phenotypes.SUMMARY: GWASs have identified several novel asthma and eczema loci as well as novel loci for IgE levels. In this review, we evaluate the interrelation between these loci and summarize to which degree recent findings on IgE reflect genetic vulnerability for atopic disease.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
asthma; eczema; genome-wide association studies; total IgE
ISSN (print) / ISBN
1528-4050
e-ISSN
1473-6322
Quellenangaben
Volume: 10,
Issue: 5,
Pages: 408-417
Publisher
Lippincott Williams & Wilkins
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)
Institute of Epidemiology (EPI)
Institute of Epidemiology (EPI)